Inflammation-Promoting Complement Fragments

D. Bitter-Suermann, J. Köhl

Abstract

The bulk of inflammatory potential of the complement system is characterized by the following items:
1.
Along the reaction sequence of the complement system split products (activation peptides) of well characterized complement proteins are generated and released which by themselves don’t influence the further activation cascade. But, as soluble factors they represent one of the three major effector mechanisms mediated by complement, i.e. inflammation.

2.
The other mechanisms are adherence, antigen- and IC-processing mediated via complement receptors for the covalently fixed C3b, iC3b and C3d, and cytolysis mediated by the membrane inserted terminal complex C5b-9 (membrane attack complex). Adherence to and membrane perturbation by C3b fragments and C5b-9 respectively contribute to pathologic sequelae exerted by actively attracted and passively affected cells in the inflammatory situation.
OriginalspracheEnglisch
TitelProgress in Immunology
Redakteure/-innenFritz Melchers, E. D. Albert, H. von Boehmer, M. P. Dierich, L. Du Pasquier, K. Eichmann, D. Gemsa, O. Götze, J. R. Kalden, S. H. E. Kaufmann, H. Kirchner, K. Resch, G. Riethmüller, A. Schimpl, C. Sorg, M. Steinmetz, H. Wagner, H. G. Zachau
Seitenumfang8
ErscheinungsortBerlin, Heidelberg
Herausgeber (Verlag)Springer Berlin Heidelberg
Erscheinungsdatum1989
Seiten186-193
ISBN (Print)978-3-642-83757-9
ISBN (elektronisch)978-3-642-83755-5
DOIs
PublikationsstatusVeröffentlicht - 1989
VeranstaltungProceedings of the 7th International Congress Immunology Berlin 1989 - berlin, Deutschland
Dauer: 01.01.198901.01.1989

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