Inflammation in takotsubo cardiomyopathy: Insights from cardiovascular magnetic resonance imaging

Ingo Eitel*, Christian Lücke, Matthias Grothoff, Mahdi Sareban, Gerhard Schuler, Holger Thiele, Matthias Gutberlet

*Korrespondierende/r Autor/-in für diese Arbeit
114 Zitate (Scopus)

Abstract

Objective: Takotsubo cardiomyopathy (TTC) is an increasingly recognised acute cardiac syndrome, whose underlying pathophysiological mechanisms remain unknown. Inflammation might play a role as this has been shown in endomyocardial biopsies. The aim of this study was to assess inflammatory parameters in patients with TTC using a comprehensive cardiovascular magnetic resonance imaging (CMR) approach. Methods: Thirty-seven patients with the suspected diagnosis of TTC underwent CMR. T2-weighted imaging to calculate the oedema ratio, T1-weighted imaging before and after contrast agent administration to calculate the global relative enhancement (gRE), and late gadolinium enhancement (LGE) imaging were performed. Results: In 11 patients CMR revealed the diagnosis of myocardial infarction (n=7; 19%) or myocarditis (n=4; 11%) with typical patterns of LGE. In all other patients (n=26; 70%), no LGE was detected consistent with the diagnosis of TTC. Of these, in 16 patients (62%) both inflammatory markers (oedema ratio and gRE) were elevated with concomitant pericardial effusion, indicating acute inflammation. Follow-up CMR after 3 months showed complete normalisation of left ventricular function and inflammatory parameters in the absence of LGE and pericardial effusion. Conclusion: This CMR study provides further insights into the pathophysiological mechanisms in TTC, supporting the contribution of an inflammatory process in the acute setting.

OriginalspracheEnglisch
ZeitschriftEuropean Radiology
Jahrgang20
Ausgabenummer2
Seiten (von - bis)422-431
Seitenumfang10
ISSN0938-7994
DOIs
PublikationsstatusVeröffentlicht - 02.2010

Strategische Forschungsbereiche und Zentren

  • Zentren: Universitäres Herzzentrum Lübeck (UHZL)

DFG-Fachsystematik

  • 205-12 Kardiologie, Angiologie

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