Abstract
Albuterol, a specific β-2 adre-nergic agonist, was found to produce a significant increase in perfusate levels of Ep in isolated perfused dog kidneys which were programmed by prior exposure to hypoxia (0.42 atm) for 2 hr. Albuterol enhanced Ep titers in perfusates in both normoxemic and hypoxemic perfused kidneys which were significantly higher than that of the Ep level seen in saline controls during a 5-hr perfusion period. The effect of albuterol on Ep production in isolated perfused kidneys was abolished by pretreatment of the dogs with the prostaglandins synthetase inhibitor indo-methacin. The inhibition of albuterol-in-duced Ep elaboration by indomethacin supports our hypothesis that prostaglandins may play a significant role in mediating β-2 ad-renergic activation of kidney Ep production.
| Originalsprache | Englisch |
|---|---|
| Zeitschrift | Proceedings of the Society for Experimental Biology and Medicine |
| Jahrgang | 162 |
| Ausgabenummer | 1 |
| Seiten (von - bis) | 65-70 |
| Seitenumfang | 6 |
| ISSN | 0037-9727 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - 10.1979 |
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)
UN SDGs
Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung
