Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy

Jannik Prasuhn; Martin Göttlich; Sinja S. Großer; Katharina Reuther; Britt Ebeling; Christina Bodemann; Henrike Hanssen; Armin M. Nagel; Norbert Brüggemann

doi:10.3390/biomedicines10071728

Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy

Jannik Prasuhn
, Martin Göttlich
, Sinja S. Großer
, Katharina Reuther
, Britt Ebeling
, Christina Bodemann
, Henrike Hanssen
, Armin M. Nagel
, Norbert Brüggemann^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Christian-Albrechts Universität zu Kiel
Friedrich-Alexander-Universität Erlangen-Nürnberg
Deutsches Krebsforschungszentrum

2 Zitate (Scopus)

Abstract

Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (²³Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) ²³Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. ²³Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.

Originalsprache	Englisch
Aufsatznummer	1728
Zeitschrift	Biomedicines
Jahrgang	10
Ausgabenummer	7
ISSN	2227-9059
DOIs	https://doi.org/10.3390/biomedicines10071728
Publikationsstatus	Veröffentlicht - 07.2022

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

2.23-07 Klinische Neurologie, Neurochirurgie und Neuroradiologie

Zugriff auf Dokument

10.3390/biomedicines10071728

Andere Dateien und Links

Link to publication in Scopus

Dieses zitieren

@article{9ae15eb9af304b3ca0d42e5061a411f9,

title = "Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy",

abstract = "Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.",

author = "Jannik Prasuhn and Martin G{\"o}ttlich and Gro{\ss}er, \{Sinja S.\} and Katharina Reuther and Britt Ebeling and Christina Bodemann and Henrike Hanssen and Nagel, \{Armin M.\} and Norbert Br{\"u}ggemann",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = jul,

doi = "10.3390/biomedicines10071728",

language = "English",

volume = "10",

journal = "Biomedicines",

issn = "2227-9059",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

TY - JOUR

T1 - Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy

AU - Prasuhn, Jannik

AU - Göttlich, Martin

AU - Großer, Sinja S.

AU - Reuther, Katharina

AU - Ebeling, Britt

AU - Bodemann, Christina

AU - Hanssen, Henrike

AU - Nagel, Armin M.

AU - Brüggemann, Norbert

PY - 2022/7

Y1 - 2022/7

N2 - Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.

AB - Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.

UR - https://www.scopus.com/pages/publications/85137284490

U2 - 10.3390/biomedicines10071728

DO - 10.3390/biomedicines10071728

M3 - Journal articles

AN - SCOPUS:85137284490

SN - 2227-9059

VL - 10

JO - Biomedicines

JF - Biomedicines

IS - 7

M1 - 1728

ER -

Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy

Abstract

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Dieses zitieren