Increased frequency of X-bearing sperm in males from an infertility clinic: Analysis by two-color fluorescence in situ hybridization

R. Johannisson*, E. Leuschner, M. Hüppe, F. Hinrichs, S. Al-Hasani, K. Diedrich, E. Schwinger, K. Mennicke

*Korrespondierende/r Autor/-in für diese Arbeit
16 Zitate (Scopus)

Abstract

Semen samples from 34 men visiting the Lübeck infertility clinic were investigated using a two-color FISH method to determine the ratio of X- and Y-bearing sperm. The overall ratio was significantly shifted to a preponderance of X-containing sperm. A statistical comparison with seven reports from the literature which included 53 normal probands demonstrated in our patients a significant tendency of a preponderance of X-bearing sperm and significantly less Y-bearing sperm. Furthermore, the Lübeck sperm samples are remarkably more heterogeneous in respect to their variability of X- and Y-bearing spermatozoa than in the other mentioned studies with normal probands. These phenomena have to be evaluated in further studies on groups of infertile males showing similar infertility histories.

OriginalspracheEnglisch
ZeitschriftCytogenetic and Genome Research
Jahrgang98
Ausgabenummer4
Seiten (von - bis)240-244
Seitenumfang5
ISSN1424-8581
DOIs
PublikationsstatusVeröffentlicht - 2002

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