Improvement of Sleep Disorders During a Course of Radiotherapy for Breast Cancer - Final Results of the Prospective Interventional RADIO-SLEEP Trial

Dirk Rades*, CARLOS A. NARVAEZ, Liesa Dziggel, Laura Splettstosser, Stefan Janssen, Denise Olbrich, STEVEN E. SCHILD, Soren Tvilsted, TROELS W. KJAER

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

Background/Aim: Upcoming radiotherapy may cause distress and sleep disorders (SDO). This prospective interventional trial investigated SDO during a course of radiotherapy for breast cancer. Patients and Methods: Fifty patients were eligible. The primary endpoint was improvement of SDO after 15 fractions. Additional endpoints included SDO after 5 fractions and at the end of radiotherapy (EOT). Additional characteristics were analysed including use of smartphones/tablets, age, body mass index, performance score, comorbidity score, surgery, distress score, and emotional/ physical/practical problems. Results: After 15 fractions, 38% of patients reported improvement of SDO (p<0.0001). Improvement rates were 22% after 5 fractions (p=0.003) and 39% at EOT (p<0.0001). Moreover, a significant association was observed for lower distress score after 5 fractions. Conclusion: Improvement of SDO occurred more often than expected, most likely due to habituation to radiotherapy. Since SDO did not improve in the majority of patients, timely psychological support should be offered to all patients.

OriginalspracheEnglisch
ZeitschriftAnticancer Research
Jahrgang42
Ausgabenummer6
Seiten (von - bis)3085-3089
Seitenumfang5
ISSN0250-7005
DOIs
PublikationsstatusVeröffentlicht - 06.2022

Strategische Forschungsbereiche und Zentren

  • Zentren: Universitäres Cancer Center Schleswig-Holstein (UCCSH)
  • Profilbereich: Lübeck Integrated Oncology Network (LION)

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