Improved synthesis of rupintrivir

Daizong Lin; Wangke Qian; Rolf Hilgenfeld; Hualiang Jiang; Kaixian Chen; Hong Liu

doi:10.1007/s11426-011-4478-5

Improved synthesis of rupintrivir

Daizong Lin, Wangke Qian, Rolf Hilgenfeld, Hualiang Jiang, Kaixian Chen, Hong Liu^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Biochemie

8 Zitate (Scopus)

Abstract

An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.

Originalsprache	Englisch
Zeitschrift	Science China Chemistry
Jahrgang	55
Ausgabenummer	6
Seiten (von - bis)	1101-1107
Seitenumfang	7
ISSN	1674-7291
DOIs	https://doi.org/10.1007/s11426-011-4478-5
Publikationsstatus	Veröffentlicht - 01.06.2012

Fördermittel

We gratefully acknowledge financial support from the National Natural Science Foundation of China (20872153, 21021063, 20720102040 and 81025017), the National Basic Research Program of China grant (2009CB918502), the Chinese Academy of Sciences (XDA01040305), and the SILVER project of the European Commission (contract HEALTH-F3-2010-260644). HR is supported by a Chinese Academy of Sciences Visiting Professorship for Senior International Scientists (2010T1S6).

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author = "Daizong Lin and Wangke Qian and Rolf Hilgenfeld and Hualiang Jiang and Kaixian Chen and Hong Liu",

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AU - Chen, Kaixian

AU - Liu, Hong

PY - 2012/6/1

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Improved synthesis of rupintrivir

Abstract

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