Impaired comprehension of temporal connectives in Parkinson's disease-A neuroimaging study

Zheng Ye, Maria Milenkova, Bahram Mohammadi, Katja Kollewe, Christoph Schrader, Reinhard Dengler, Amir Samii, Thomas F. Münte*

*Korrespondierende/r Autor/-in für diese Arbeit
6 Zitate (Scopus)

Abstract

Parkinson's disease has been found to impair comprehension of complex sentences. Here we follow up on earlier findings that sentences describing two successive events in the form of ". Before B, A" are understood worse by Parkinson patients than sentences in the form of ". After A, B". Before-initial sentences express events in an order inconsistent with their actual order of occurrence and therefore require additional computations during comprehension. In a behavioral study we tested whether 28 German Parkinson patients reading 'before'- and 'after'-initial sentences correctly understood the sequence of events. A second functional magnetic resonance imaging study investigated 16 different patients who read sentences while in the scanner. The behavioral study revealed that 'before' sentences were misunderstood with regard to the temporal sequence of events in 53% (controls 6.5%). The imaging study demonstrated a functional network of the caudate nucleus, middle frontal gyrus, medial superior frontal gyrus, parietal lobule and inferior temporal gyrus. This network was dynamically modulated for 'before' compared to 'after' sentences in healthy controls but not in Parkinson patients. The current results suggest that the additional computations required for 'before' sentences are supported by a network with the caudate nucleus as a central element. This network was compromised in Parkinson patients. We propose that dysfunction of the caudate nucleus networks underlies Parkinson patients' difficulty in dealing with complex sentence structures.

OriginalspracheEnglisch
ZeitschriftNeuropsychologia
Jahrgang50
Ausgabenummer8
Seiten (von - bis)1794-1800
Seitenumfang7
ISSN0028-3932
DOIs
PublikationsstatusVeröffentlicht - 01.07.2012

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