Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity

Dirk Friedrich; Roger A. Fecher; Jan Rupp; George S. Deepe

doi:10.1016/j.micinf.2016.10.008

Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity

Dirk Friedrich^*, Roger A. Fecher, Jan Rupp, George S. Deepe

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Infektiologie und Mikrobiologie

University of Cincinnati

3 Zitate (Scopus)

Abstract

Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.

Originalsprache	Englisch
Zeitschrift	Microbes and Infection
Jahrgang	19
Ausgabenummer	3
Seiten (von - bis)	204-209
Seitenumfang	6
ISSN	1286-4579
DOIs	https://doi.org/10.1016/j.micinf.2016.10.008
Publikationsstatus	Veröffentlicht - 01.03.2017

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Dokumente

10.1016/j.micinf.2016.10.008

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abstract = "Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.",

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AU - Fecher, Roger A.

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AU - Deepe, George S.

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AB - Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.

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Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity

Abstract

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