Impact of Dose-Volume Parameters of Parotid Glands on Xerostomia in Patients Irradiated for Head-and-Neck Cancer

Dirk Rades*, Britta Warwas, Florian Cremers, Karsten Gerull, Christian Idel, Karl L. Bruchhage, Samer G. Hakim, Steven E. Schild

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

Background/Aim: Optimal planning of radiotherapy for head-and-neck cancers should consider the risk of xerostomia. This study investigated the prognostic value of dose-volume parameters of the parotid glands. Patients and Methods: Dose-volume parameters were evaluated for xerostomia in 145 patients including D40 (minimum dose to 40% of corresponding parotid volume), D60 (minimum dose to 60%), D80 (minimum dose to 80%), and mean dose of ipsilateral, contralateral, and bilateral parotid glands. Results: Grade ≥2 xerostomia was significantly associated with D40 of ipsilateral and all parameters of bilateral glands; trends were found for all other parameters. Grade ≥3 xerostomia was significantly associated with D80 of bilateral glands; trends were found for other parameters of ipsilateral and bilateral glands. Conclusion: Since grade ≥2 xerostomia was associated with all parameters, D40, D60, and D80 did not provide additional information to mean doses. D80 of bilateral glands is a new factor and more predictive than mean dose regarding grade ≥3 xerostomia.

OriginalspracheEnglisch
ZeitschriftAnticancer Research
Jahrgang42
Ausgabenummer7
Seiten (von - bis)3551-3556
Seitenumfang6
ISSN0250-7005
DOIs
PublikationsstatusVeröffentlicht - 07.2022

Strategische Forschungsbereiche und Zentren

  • Profilbereich: Lübeck Integrated Oncology Network (LION)
  • Zentren: Universitäres Cancer Center Schleswig-Holstein (UCCSH)

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