Impact of cyclooxygenase-2 in breast cancer

Friederike Hoellen; Katharina Kelling; Christine Dittmer; Klaus Diedrich; Michael Friedrich; Marc Thill

Impact of cyclooxygenase-2 in breast cancer

Friederike Hoellen, Katharina Kelling, Christine Dittmer, Klaus Diedrich, Michael Friedrich, Marc Thill^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Frauenheilkunde und Geburtshilfe

32 Zitate (Scopus)

Abstract

Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.

Originalsprache	Englisch
Zeitschrift	Anticancer Research
Jahrgang	31
Ausgabenummer	12
Seiten (von - bis)	4359-4367
Seitenumfang	9
ISSN	0250-7005
Publikationsstatus	Veröffentlicht - 01.12.2011

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AU - Hoellen, Friederike

AU - Kelling, Katharina

AU - Dittmer, Christine

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AU - Friedrich, Michael

AU - Thill, Marc

PY - 2011/12/1

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N2 - Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.

AB - Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.

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M3 - Scientific review articles

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JO - Anticancer Research

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Impact of cyclooxygenase-2 in breast cancer

Abstract

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