IL12B and IL23R polymorphisms are associated with alopecia areata

Pardis Sadat Tabatabaei-Panah, Hamideh Moravvej, Sara Delpasand, Mona Jafari, Sanaz Sepehri, Reyhaneh Abgoon, Ralf J. Ludwig, Reza Akbarzadeh*

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

Alopecia areata is an autoimmune disease in which activation of autoreactive T cells and inflammatory immune signals target the hair follicles autoantigens. Although cytokines are involved in regulating autoimmune inflammation, the specific involvement of these molecules in the pathogenesis of alopecia areata has been remained unsettled. Here, a possible influence of IL12B, IL17A, and IL23R variations on susceptibility to alopecia areata in Iranian patients was investigated. Genotyping of IL12B (rs3212227), IL17A (rs2275913), and IL23R (rs10889677) variants were performed by extracting genomic DNA from patients and controls. Gene expression was analyzed by real-time RT-PCR. The frequency of IL12B and IL23R gene polymorphisms is significantly higher in the patients than controls, while no significant difference was found for IL17A. Stratification of the patients with respect to age at disease onset indicated that CC genotype of IL12B (rs3212227) and AA genotype of IL23R (rs10889677) gene polymorphisms are significantly associated with late-onset alopecia areata disease. In contrast to IL17A and IL23R, IL12B gene expression levels elevated in patients to that of controls, but genotypes had no effect on levels of gene expression. Overall, our data confirmed that the IL12B and IL23R polymorphisms are associated with the risk to develop alopecia areata in our population.

OriginalspracheEnglisch
ZeitschriftGenes and Immunity
Jahrgang21
Ausgabenummer3
Seiten (von - bis)203-210
Seitenumfang8
ISSN1466-4879
DOIs
PublikationsstatusVeröffentlicht - 01.05.2020

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

Fingerprint

Untersuchen Sie die Forschungsthemen von „IL12B and IL23R polymorphisms are associated with alopecia areata“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren