IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease

Adrian Baican; Yoshiaki Hirako; Zelmira Lazarova; Kim B. Yancey; Detlef Zillikens; Cassian Sitaru

doi:10.1016/j.jaad.2005.05.001

IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease

Adrian Baican, Yoshiaki Hirako, Zelmira Lazarova, Kim B. Yancey, Detlef Zillikens^*, Cassian Sitaru

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Dermatologie, Allergologie und Venerologie

9 Zitate (Scopus)

Abstract

We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.

Originalsprache	Englisch
Zeitschrift	Journal of the American Academy of Dermatology
Jahrgang	53
Ausgabenummer	3
Seiten (von - bis)	516-521
Seitenumfang	6
ISSN	0190-9622
DOIs	https://doi.org/10.1016/j.jaad.2005.05.001
Publikationsstatus	Veröffentlicht - 09.2005

Fördermittel

Funding source: Grant Zi 439/6-1 from the Deutsche Forschungsgemeinschaft.

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10.1016/j.jaad.2005.05.001

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@article{5aaeca6191bf4d158f7d36f1ed75332d,

title = "IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease",

abstract = "We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.",

author = "Adrian Baican and Yoshiaki Hirako and Zelmira Lazarova and Yancey, \{Kim B.\} and Detlef Zillikens and Cassian Sitaru",

note = "Funding Information: Funding source: Grant Zi 439/6-1 from the Deutsche Forschungsgemeinschaft. ",

year = "2005",

month = sep,

doi = "10.1016/j.jaad.2005.05.001",

language = "English",

volume = "53",

pages = "516--521",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

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}

IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease. / Baican, Adrian; Hirako, Yoshiaki; Lazarova, Zelmira et al.
in: Journal of the American Academy of Dermatology, Jahrgang 53, Nr. 3, 09.2005, S. 516-521.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease

AU - Baican, Adrian

AU - Hirako, Yoshiaki

AU - Lazarova, Zelmira

AU - Yancey, Kim B.

AU - Zillikens, Detlef

AU - Sitaru, Cassian

N1 - Funding Information: Funding source: Grant Zi 439/6-1 from the Deutsche Forschungsgemeinschaft.

PY - 2005/9

Y1 - 2005/9

N2 - We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.

AB - We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.

UR - https://www.scopus.com/pages/publications/23944434751

U2 - 10.1016/j.jaad.2005.05.001

DO - 10.1016/j.jaad.2005.05.001

M3 - Journal articles

C2 - 16112366

AN - SCOPUS:23944434751

SN - 0190-9622

VL - 53

SP - 516

EP - 521

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 3

ER -

IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease

Abstract

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UN SDGs

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