TY - JOUR
T1 - IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease
AU - Baican, Adrian
AU - Hirako, Yoshiaki
AU - Lazarova, Zelmira
AU - Yancey, Kim B.
AU - Zillikens, Detlef
AU - Sitaru, Cassian
N1 - Funding Information:
Funding source: Grant Zi 439/6-1 from the Deutsche Forschungsgemeinschaft.
PY - 2005/9
Y1 - 2005/9
N2 - We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.
AB - We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.
UR - http://www.scopus.com/inward/record.url?scp=23944434751&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2005.05.001
DO - 10.1016/j.jaad.2005.05.001
M3 - Journal articles
C2 - 16112366
AN - SCOPUS:23944434751
SN - 0190-9622
VL - 53
SP - 516
EP - 521
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 3
ER -
