Hypoxia-inducible factor-1: More than a hypoxia-inducible transcription factor

Thomas Hellwig-Bürgel, Daniel Phillip Stiehl, Wolfgang Jelkmann

3 Zitate (Scopus)

Abstract

Transcription is an energy-consuming process. From an economical view it is reasonable that not all genes are transcribed simultaneously in one cell. Indeed, most genes are transcribed only when a specific gene product is needed. Regulation of gene expression is mainly achieved by the coordinate interplay of different transcription factors (TFs) and transcriptional coactivators with DNA-dependent RNA-polymerases. To gain spatial and temporal control in this process, TFs have to fulfill two prerequisites: sequence specificity and inducibility.

OriginalspracheEnglisch
TitelOxygen Sensing : Responses and Adaption to Hypoxia
Seitenumfang16
Herausgeber (Verlag)CRC Press
Erscheinungsdatum01.01.2003
Seiten93-108
ISBN (Print)9780824709600
ISBN (elektronisch)9780824748456
PublikationsstatusVeröffentlicht - 01.01.2003

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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