Humoral immunity and long-lived plasma cells

Rudolf A. Manz; Sergio Arce; Giuliana Cassese; Anja E. Hauser; Falk Hiepe; Andreas Radbruch

doi:10.1016/S0952-7915(02)00356-4

Humoral immunity and long-lived plasma cells

Rudolf A. Manz^*, Sergio Arce, Giuliana Cassese, Anja E. Hauser, Falk Hiepe, Andreas Radbruch

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Systemische Entzündungsforschung

Charite - Universitatsmedizin Berlin

187 Zitate (Scopus)

Abstract

A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with a current model for lymphocyte homeostasis, the lifetime of long-lived plasma cells is probably regulated by competition for a limited number of survival niches present in splenic red pulp, bone marrow and inflamed tissue. Plasma cells secreting autoantibodies specific for some, but not all, self-antigens are probably 'allowed' to enter the compartment of long-lived plasma cells and provide antibody-mediated 'autoimmune memory' that is resistant to conventional therapies.

Originalsprache	Englisch
Zeitschrift	Current Opinion in Immunology
Jahrgang	14
Ausgabenummer	4
Seiten (von - bis)	517-521
Seitenumfang	5
ISSN	0952-7915
DOIs	https://doi.org/10.1016/S0952-7915(02)00356-4
Publikationsstatus	Veröffentlicht - 01.08.2002

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This work was supported by the Deutsche Forschungsgemeinschaft grant numbers MA 2273 and SFB421/C4.

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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10.1016/S0952-7915(02)00356-4

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title = "Humoral immunity and long-lived plasma cells",

abstract = "A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with a current model for lymphocyte homeostasis, the lifetime of long-lived plasma cells is probably regulated by competition for a limited number of survival niches present in splenic red pulp, bone marrow and inflamed tissue. Plasma cells secreting autoantibodies specific for some, but not all, self-antigens are probably 'allowed' to enter the compartment of long-lived plasma cells and provide antibody-mediated 'autoimmune memory' that is resistant to conventional therapies.",

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T1 - Humoral immunity and long-lived plasma cells

AU - Manz, Rudolf A.

AU - Arce, Sergio

AU - Cassese, Giuliana

AU - Hauser, Anja E.

AU - Hiepe, Falk

AU - Radbruch, Andreas

N1 - Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft grant numbers MA 2273 and SFB421/C4.

PY - 2002/8/1

Y1 - 2002/8/1

N2 - A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with a current model for lymphocyte homeostasis, the lifetime of long-lived plasma cells is probably regulated by competition for a limited number of survival niches present in splenic red pulp, bone marrow and inflamed tissue. Plasma cells secreting autoantibodies specific for some, but not all, self-antigens are probably 'allowed' to enter the compartment of long-lived plasma cells and provide antibody-mediated 'autoimmune memory' that is resistant to conventional therapies.

AB - A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with a current model for lymphocyte homeostasis, the lifetime of long-lived plasma cells is probably regulated by competition for a limited number of survival niches present in splenic red pulp, bone marrow and inflamed tissue. Plasma cells secreting autoantibodies specific for some, but not all, self-antigens are probably 'allowed' to enter the compartment of long-lived plasma cells and provide antibody-mediated 'autoimmune memory' that is resistant to conventional therapies.

UR - https://www.scopus.com/pages/publications/0036668252

U2 - 10.1016/S0952-7915(02)00356-4

DO - 10.1016/S0952-7915(02)00356-4

M3 - Scientific review articles

C2 - 12088688

AN - SCOPUS:0036668252

SN - 0952-7915

VL - 14

SP - 517

EP - 521

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 4

ER -

Humoral immunity and long-lived plasma cells

Abstract

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