HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams

Wolfgang Göpel; Kirstin Fehlau; Martina Kohl; Christian Schultz; Jens Möller

doi:10.1515/JPM.2002.023

HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams

Wolfgang Göpel^*, Kirstin Fehlau, Martina Kohl, Christian Schultz, Jens Möller

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Kinder- und Jugendmedizin

3 Zitate (Scopus)

Abstract

Objective: In cohorts of infants with proven neonatal alloimmune thrombocytopenia (NAIT) an unusual high rate of preterm infants has been reported, raising the question of whether NAIT contributes to the high rate of intracranial hemorrhage in preterm infants. Methods: We genotyped the HPA-1-allele in a large cohort of term (n = 205) and very low birth weight infants (VLBW-infants, n = 299) with polymerase-chain-reaction and restriction enzyme digestion. Results: HPA-la/b is the only fetal HPA-1-genotype in which alloimmunization and NAIT could occur. Genotype distribution did not differ between term and VLBW-infants (p = 0.26). Furthermore, neither HPA-la/b genotype nor platelet count at birth were of significant prognostic value in predicting subsequent intracranial haemorrhage or death in VLBW-infants (p = 0.93 and V = 0.19 respectively). Conclusion: Our data did not support the hypothesis that routine screening of preterm infants or their mothers for HPA-1-genotype is of additional value in the care of these infants.

Originalsprache	Englisch
Zeitschrift	Journal of Perinatal Medicine
Jahrgang	30
Ausgabenummer	2
Seiten (von - bis)	176-178
Seitenumfang	3
ISSN	0300-5577
DOIs	https://doi.org/10.1515/JPM.2002.023
Publikationsstatus	Veröffentlicht - 2002

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Acknowledgment: The authors thank Lynn Ellenberg for excellent laboratory assistance and Dr. Friedrich of the Institute for Medical Statistics of the University of Lçbeck for the logistic regression analysis. This study was supported by grant GO-955/1-1 from the Deutsche Forschungsgemeinschaft.

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SDG 3 – Gesundheit und Wohlergehen
SDG 5 – Gender Equality

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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10.1515/JPM.2002.023

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title = "HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams",

abstract = "Objective: In cohorts of infants with proven neonatal alloimmune thrombocytopenia (NAIT) an unusual high rate of preterm infants has been reported, raising the question of whether NAIT contributes to the high rate of intracranial hemorrhage in preterm infants. Methods: We genotyped the HPA-1-allele in a large cohort of term (n = 205) and very low birth weight infants (VLBW-infants, n = 299) with polymerase-chain-reaction and restriction enzyme digestion. Results: HPA-la/b is the only fetal HPA-1-genotype in which alloimmunization and NAIT could occur. Genotype distribution did not differ between term and VLBW-infants (p = 0.26). Furthermore, neither HPA-la/b genotype nor platelet count at birth were of significant prognostic value in predicting subsequent intracranial haemorrhage or death in VLBW-infants (p = 0.93 and V = 0.19 respectively). Conclusion: Our data did not support the hypothesis that routine screening of preterm infants or their mothers for HPA-1-genotype is of additional value in the care of these infants.",

author = "Wolfgang G{\"o}pel and Kirstin Fehlau and Martina Kohl and Christian Schultz and Jens M{\"o}ller",

note = "Funding Information: Acknowledgment: The authors thank Lynn Ellenberg for excellent laboratory assistance and Dr. Friedrich of the Institute for Medical Statistics of the University of L{\c c}beck for the logistic regression analysis. This study was supported by grant GO-955/1-1 from the Deutsche Forschungsgemeinschaft. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2002",

doi = "10.1515/JPM.2002.023",

language = "English",

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pages = "176--178",

journal = "Journal of Perinatal Medicine",

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T1 - HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams

AU - Göpel, Wolfgang

AU - Fehlau, Kirstin

AU - Kohl, Martina

AU - Schultz, Christian

AU - Möller, Jens

N1 - Funding Information: Acknowledgment: The authors thank Lynn Ellenberg for excellent laboratory assistance and Dr. Friedrich of the Institute for Medical Statistics of the University of Lçbeck for the logistic regression analysis. This study was supported by grant GO-955/1-1 from the Deutsche Forschungsgemeinschaft. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2002

Y1 - 2002

N2 - Objective: In cohorts of infants with proven neonatal alloimmune thrombocytopenia (NAIT) an unusual high rate of preterm infants has been reported, raising the question of whether NAIT contributes to the high rate of intracranial hemorrhage in preterm infants. Methods: We genotyped the HPA-1-allele in a large cohort of term (n = 205) and very low birth weight infants (VLBW-infants, n = 299) with polymerase-chain-reaction and restriction enzyme digestion. Results: HPA-la/b is the only fetal HPA-1-genotype in which alloimmunization and NAIT could occur. Genotype distribution did not differ between term and VLBW-infants (p = 0.26). Furthermore, neither HPA-la/b genotype nor platelet count at birth were of significant prognostic value in predicting subsequent intracranial haemorrhage or death in VLBW-infants (p = 0.93 and V = 0.19 respectively). Conclusion: Our data did not support the hypothesis that routine screening of preterm infants or their mothers for HPA-1-genotype is of additional value in the care of these infants.

AB - Objective: In cohorts of infants with proven neonatal alloimmune thrombocytopenia (NAIT) an unusual high rate of preterm infants has been reported, raising the question of whether NAIT contributes to the high rate of intracranial hemorrhage in preterm infants. Methods: We genotyped the HPA-1-allele in a large cohort of term (n = 205) and very low birth weight infants (VLBW-infants, n = 299) with polymerase-chain-reaction and restriction enzyme digestion. Results: HPA-la/b is the only fetal HPA-1-genotype in which alloimmunization and NAIT could occur. Genotype distribution did not differ between term and VLBW-infants (p = 0.26). Furthermore, neither HPA-la/b genotype nor platelet count at birth were of significant prognostic value in predicting subsequent intracranial haemorrhage or death in VLBW-infants (p = 0.93 and V = 0.19 respectively). Conclusion: Our data did not support the hypothesis that routine screening of preterm infants or their mothers for HPA-1-genotype is of additional value in the care of these infants.

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HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams

Abstract

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