Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Vinko Palada; Janoš Terzić; Joseph Mazzulli; Grace Bwala; Johann Hagenah; Borut Peterlin; Albert Y. Hung; Christine Klein; Dimitri Krainc

doi:10.1016/j.neurobiolaging.2011.06.015

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Vinko Palada, Janoš Terzić, Joseph Mazzulli, Grace Bwala, Johann Hagenah, Borut Peterlin, Albert Y. Hung, Christine Klein, Dimitri Krainc^*

^*Korrespondierende/r Autor/-in für diese Arbeit

34 Zitate (Scopus)

Abstract

Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ ² = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.

Originalsprache	Englisch
Zeitschrift	Neurobiology of Aging
Jahrgang	33
Ausgabenummer	4
ISSN	0197-4580
DOIs	https://doi.org/10.1016/j.neurobiolaging.2011.06.015
Publikationsstatus	Veröffentlicht - 01.04.2012

Fördermittel

Dr. Johann Hagenah receives research support from the Bachmann-Strauss Dystonia Parkinson Foundation and received honoraria as an invited speaker from GlaxoSmithKline. Dr. Christine Klein received consulting fees from Boehringer Ingelheim and Centogene and received honoraria for speaking from Boehringer Ingelheim and Merz Pharma. Dr. Klein is the recipient of a career development award from the Hermann and Lilly Schilling Foundation. She is funded by the Volkswagen Foundation, the Deutsche Forschungsgemeinschaft, the Possehl Foundation and received institutional support from the University of Lübeck for genetics research. Dr. Dimitri Krainc receives research support from Novartis Pharma. The remaining authors disclose no conflicts of interest. This study was approved by the institutional ethical committee. Written informed consent was obtained from all participants in the study. This study was sponsored by National Parkinson Foundation (DK), GENEPARK ( EU-LSHB-CT-2006-037544 ) grant (DK), Volkswagen Foundation, Hermann and Lilly Schilling Foundation, and NGFN Plus PNP-01GS08135-3 (BMBF, CK). Appendix A

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 10 – Weniger Ungleichheiten

Dokumente

10.1016/j.neurobiolaging.2011.06.015

Weitere Links

Link to publication in Scopus

Zitieren

@article{13a91d1fcfd7451297be82f38ddfaeeb,

title = "Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease",

abstract = "Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ 2 = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.",

author = "Vinko Palada and Jano{\v s} Terzi{\'c} and Joseph Mazzulli and Grace Bwala and Johann Hagenah and Borut Peterlin and Hung, \{Albert Y.\} and Christine Klein and Dimitri Krainc",

year = "2012",

month = apr,

day = "1",

doi = "10.1016/j.neurobiolaging.2011.06.015",

language = "English",

volume = "33",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

AU - Palada, Vinko

AU - Terzić, Janoš

AU - Mazzulli, Joseph

AU - Bwala, Grace

AU - Hagenah, Johann

AU - Peterlin, Borut

AU - Hung, Albert Y.

AU - Klein, Christine

AU - Krainc, Dimitri

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ 2 = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.

AB - Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ 2 = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.

UR - https://www.scopus.com/pages/publications/84856967226

U2 - 10.1016/j.neurobiolaging.2011.06.015

DO - 10.1016/j.neurobiolaging.2011.06.015

M3 - Journal articles

C2 - 21794955

AN - SCOPUS:84856967226

SN - 0197-4580

VL - 33

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 4

ER -

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Abstract

Fördermittel

UN SDGs

Dokumente

Weitere Links

Fingerprint

Zitieren