Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Vinko Palada; Janoš Terzić; Joseph Mazzulli; Grace Bwala; Johann Hagenah; Borut Peterlin; Albert Y. Hung; Christine Klein; Dimitri Krainc

doi:10.1016/j.neurobiolaging.2011.06.015

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Vinko Palada, Janoš Terzić, Joseph Mazzulli, Grace Bwala, Johann Hagenah, Borut Peterlin, Albert Y. Hung, Christine Klein, Dimitri Krainc^*

^*Korrespondierende/r Autor/-in für diese Arbeit

19 Zitate (Scopus)

Abstract

Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ ² = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.

Originalsprache	Englisch
Zeitschrift	Neurobiology of Aging
Jahrgang	33
Ausgabenummer	4
ISSN	0197-4580
DOIs	https://doi.org/10.1016/j.neurobiolaging.2011.06.015
Publikationsstatus	Veröffentlicht - 01.04.2012

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title = "Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease",

abstract = "Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ 2 = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.",

author = "Vinko Palada and Jano{\v s} Terzi{\'c} and Joseph Mazzulli and Grace Bwala and Johann Hagenah and Borut Peterlin and Hung, {Albert Y.} and Christine Klein and Dimitri Krainc",

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T1 - Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

AU - Palada, Vinko

AU - Terzić, Janoš

AU - Mazzulli, Joseph

AU - Bwala, Grace

AU - Hagenah, Johann

AU - Peterlin, Borut

AU - Hung, Albert Y.

AU - Klein, Christine

AU - Krainc, Dimitri

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ 2 = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.

AB - Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ 2 = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.

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U2 - 10.1016/j.neurobiolaging.2011.06.015

DO - 10.1016/j.neurobiolaging.2011.06.015

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AN - SCOPUS:84856967226

SN - 0197-4580

VL - 33

JO - Neurobiology of Aging

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ER -

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Abstract

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