High gradient nested Halbach system for steering magnetic particles

To transport drugs within the brain to their desired application site it is necessary to overcome the blood brain barrier (BBB). To protect the brain from the penetration of harmful substances, the BBB forms an endogenous protection. Different approaches exist to overcome the BBB. One possible approach are magnetic nanoparticles which can be used to move drugs through the blood-brain barrier using magnetic guidance. The system described here consists of three rings of permanent magnets in Halbach configuration with an inner diameter of 5.5 cm, which generate a high gradient of 5.8 T/m at the center. The system is used as a demonstrator for future BBB experiments and to study the effect of application time and gradient strength on the transport mechanism.