HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

Albertus T. J. Wierenga; Alan Cunningham; Ayşegül Erdem; Nuria Vilaplana Lopera; Annet Z. Brouwers-Vos; Maurien Pruis; André B. Mulder; Ulrich L. Günther; Joost H. A. Martens; Edo Vellenga; Jan Jacob Schuringa

doi:10.1186/s40170-019-0206-y

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga, Jan Jacob Schuringa

Institut für Chemie und Metabolomics

Abstract

Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state.

Originalsprache	Englisch
Aufsatznummer	11
Zeitschrift	Cancer & Metabolism
Jahrgang	7
Ausgabenummer	1
ISSN	2049-3002
DOIs	https://doi.org/10.1186/s40170-019-0206-y
Publikationsstatus	Veröffentlicht - 27.12.2019

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10.1186/s40170-019-0206-y

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Wierenga, A. T. J., Cunningham, A., Erdem, A., Lopera, N. V., Brouwers-Vos, A. Z., Pruis, M., Mulder, A. B., Günther, U. L., Martens, J. H. A., Vellenga, E., & Schuringa, J. J. (2019). HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells. Cancer & Metabolism, 7(1), Artikel 11. https://doi.org/10.1186/s40170-019-0206-y

@article{9f70c194e4bf492cb9607dd61ab8c325,

title = "HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells",

abstract = "Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state.",

author = "Wierenga, \{Albertus T. J.\} and Alan Cunningham and Ay{\c s}eg{\"u}l Erdem and Lopera, \{Nuria Vilaplana\} and Brouwers-Vos, \{Annet Z.\} and Maurien Pruis and Mulder, \{Andr{\'e} B.\} and G{\"u}nther, \{Ulrich L.\} and Martens, \{Joost H. A.\} and Edo Vellenga and Schuringa, \{Jan Jacob\}",

year = "2019",

month = dec,

day = "27",

doi = "10.1186/s40170-019-0206-y",

language = "English",

volume = "7",

journal = "Cancer \& Metabolism",

issn = "2049-3002",

number = "1",

}

Wierenga, ATJ, Cunningham, A, Erdem, A, Lopera, NV, Brouwers-Vos, AZ, Pruis, M, Mulder, AB, Günther, UL, Martens, JHA, Vellenga, E & Schuringa, JJ 2019, 'HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells', Cancer & Metabolism, Jg. 7, Nr. 1, 11. https://doi.org/10.1186/s40170-019-0206-y

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells. / Wierenga, Albertus T. J.; Cunningham, Alan; Erdem, Ayşegül et al.
in: Cancer & Metabolism, Jahrgang 7, Nr. 1, 11, 27.12.2019.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

AU - Wierenga, Albertus T. J.

AU - Cunningham, Alan

AU - Erdem, Ayşegül

AU - Lopera, Nuria Vilaplana

AU - Brouwers-Vos, Annet Z.

AU - Pruis, Maurien

AU - Mulder, André B.

AU - Günther, Ulrich L.

AU - Martens, Joost H. A.

AU - Vellenga, Edo

AU - Schuringa, Jan Jacob

PY - 2019/12/27

Y1 - 2019/12/27

N2 - Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state.

AB - Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state.

UR - https://www.researchgate.net/publication/338199401_HIF12-exerted_control_over_glycolytic_gene_expression_is_not_functionally_relevant_for_glycolysis_in_human_leukemic_stemprogenitor_cells

U2 - 10.1186/s40170-019-0206-y

DO - 10.1186/s40170-019-0206-y

M3 - Journal articles

SN - 2049-3002

VL - 7

JO - Cancer & Metabolism

JF - Cancer & Metabolism

IS - 1

M1 - 11

ER -

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

Abstract

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