Hexafluoroacetone as protecting and activating reagent: Site-selective functionalization of α-amino alkanedioic acids

Thomas Rühl; Christoph Böttcher; Ksenia Pumpor; Lothar Hennig; Joachim Sieler; Klaus Burger

doi:10.1055/s-2004-834918

Hexafluoroacetone as protecting and activating reagent: Site-selective functionalization of α-amino alkanedioic acids

Thomas Rühl^*, Christoph Böttcher, Ksenia Pumpor, Lothar Hennig, Joachim Sieler, Klaus Burger

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Biochemie

Universität Leipzig

6 Zitate (Scopus)

Abstract

Methodology for the site-selective functionalization of α-amino alkanedioic acids (Asp, Glu and homologues) using hexafluoroacetone as protecting and activating reagent is described. Via new types of dielectrophiles, alternative approaches to multifunctional non-natural amino acids and some of their conjugates become readily available.

Originalsprache	Englisch
Zeitschrift	Synthesis
Ausgabenummer	18
Seiten (von - bis)	3065-3069
Seitenumfang	5
ISSN	0039-7881
DOIs	https://doi.org/10.1055/s-2004-834918
Publikationsstatus	Veröffentlicht - 17.12.2004

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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10.1055/s-2004-834918

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title = "Hexafluoroacetone as protecting and activating reagent: Site-selective functionalization of α-amino alkanedioic acids",

abstract = "Methodology for the site-selective functionalization of α-amino alkanedioic acids (Asp, Glu and homologues) using hexafluoroacetone as protecting and activating reagent is described. Via new types of dielectrophiles, alternative approaches to multifunctional non-natural amino acids and some of their conjugates become readily available.",

author = "Thomas R{\"u}hl and Christoph B{\"o}ttcher and Ksenia Pumpor and Lothar Hennig and Joachim Sieler and Klaus Burger",

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T1 - Hexafluoroacetone as protecting and activating reagent: Site-selective functionalization of α-amino alkanedioic acids

AU - Rühl, Thomas

AU - Böttcher, Christoph

AU - Pumpor, Ksenia

AU - Hennig, Lothar

AU - Sieler, Joachim

AU - Burger, Klaus

PY - 2004/12/17

Y1 - 2004/12/17

N2 - Methodology for the site-selective functionalization of α-amino alkanedioic acids (Asp, Glu and homologues) using hexafluoroacetone as protecting and activating reagent is described. Via new types of dielectrophiles, alternative approaches to multifunctional non-natural amino acids and some of their conjugates become readily available.

AB - Methodology for the site-selective functionalization of α-amino alkanedioic acids (Asp, Glu and homologues) using hexafluoroacetone as protecting and activating reagent is described. Via new types of dielectrophiles, alternative approaches to multifunctional non-natural amino acids and some of their conjugates become readily available.

UR - https://www.scopus.com/pages/publications/11144283082

U2 - 10.1055/s-2004-834918

DO - 10.1055/s-2004-834918

M3 - Journal articles

AN - SCOPUS:11144283082

SN - 0039-7881

SP - 3065

EP - 3069

JO - Synthesis

JF - Synthesis

IS - 18

ER -

Hexafluoroacetone as protecting and activating reagent: Site-selective functionalization of α-amino alkanedioic acids

Abstract

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