Abstract
Current systemic cancer treatment in head and neck squamous cell carcinoma (HNSCC) is moving toward more personalized approaches such as de-escalation protocols human-papilloma-virus dependent HNSCC or application of checkpoint inhibitors. However, these treatments have been challenged by cancer stem cells (CSC), a small population within the bulk tumor, which are leading to treatment failure, tumor recurrence, or metastases. This review will give an overview of the characteristics of HNSCC-CSC. Specifically, the mechanisms by which HNSCC-CSC induce tumor initiation, progression, recurrence, or metastasis will be discussed. Although evidence-based treatment options targeting HNSCC-CSC specifically are still being sought for, they warrant a promise for additional and sustainable treatment options where for HNSCC patients where others have failed.
Originalsprache | Englisch |
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Titel | Advances in Experimental Medicine and Biology |
Redakteure/-innen | Alexander Birbrair |
Seitenumfang | 18 |
Erscheinungsort | Cham |
Herausgeber (Verlag) | Springer New York LLC |
Erscheinungsdatum | 28.05.2019 |
Seiten | 23-40 |
ISBN (Print) | 978-3-030-14365-7 |
ISBN (elektronisch) | 978-3-030-14366-4 |
DOIs | |
Publikationsstatus | Veröffentlicht - 28.05.2019 |
Strategische Forschungsbereiche und Zentren
- Profilbereich: Lübeck Integrated Oncology Network (LION)