Heterogeneity of head and neck squamous cell carcinoma stem cells

Xu Qian, Xiaobo Nie, Barbara Wollenberg, Holger Sudhoff, Andreas M. Kaufmann, Andreas E. Albers*

*Korrespondierende/r Autor/-in für diese Arbeit
4 Zitate (Scopus)


Current systemic cancer treatment in head and neck squamous cell carcinoma (HNSCC) is moving toward more personalized approaches such as de-escalation protocols human-papilloma-virus dependent HNSCC or application of checkpoint inhibitors. However, these treatments have been challenged by cancer stem cells (CSC), a small population within the bulk tumor, which are leading to treatment failure, tumor recurrence, or metastases. This review will give an overview of the characteristics of HNSCC-CSC. Specifically, the mechanisms by which HNSCC-CSC induce tumor initiation, progression, recurrence, or metastasis will be discussed. Although evidence-based treatment options targeting HNSCC-CSC specifically are still being sought for, they warrant a promise for additional and sustainable treatment options where for HNSCC patients where others have failed.

TitelAdvances in Experimental Medicine and Biology
Redakteure/-innenAlexander Birbrair
Herausgeber (Verlag)Springer New York LLC
ISBN (Print)978-3-030-14365-7
ISBN (elektronisch)978-3-030-14366-4
PublikationsstatusVeröffentlicht - 28.05.2019

Strategische Forschungsbereiche und Zentren

  • Profilbereich: Lübeck Integrated Oncology Network (LION)


Untersuchen Sie die Forschungsthemen von „Heterogeneity of head and neck squamous cell carcinoma stem cells“. Zusammen bilden sie einen einzigartigen Fingerprint.