Goal-directed colloid administration improves the microcirculation of healthy and perianastomotic colon

Oliver Kimberger*, Michael Arnberger, Sebastian Brandt, Jan Plock, Gisli H. Sigurdsson, Andrea Kurz, Luzius Hiltebrand

*Korrespondierende/r Autor/-in für diese Arbeit
104 Zitate (Scopus)

Abstract

BACKGROUND: The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis surgery. METHODS: Pigs (n = 27, 9 per group) were anesthetized and mechanically ventilated. A hand-sewn colon anastomosis was performed. The animals were subsequently randomized to one of the following treatments: R-RL group, 3 ml • kg • h Ringer lactate (RL); GD-RL group, 3 ml • kg • h RL + bolus 250 ml of RL; GD-C group, 3 ml • kg • h RL + bolus 250 ml of hydroxyethyl starch (HES 6%, 130/0.4). A fluid bolus was administered when mixed venous oxygen saturation dropped below 60%. Intestinal tissue oxygen tension and microcirculatory blood flow were measured continuously. RESULTS: After 4 h of treatment, tissue oxygen tension in healthy colon increased to 150 ± 31% in group GD-C versus 123 ± 40% in group GD-RL versus 94 ± 23% in group R-RL (percent of postoperative baseline values, mean ± SD; P < 0.01). Similarly perianastomotic tissue oxygen tension increased to 245 ± 93% in the GD-C group versus 147 ± 58% in the GD-RL group and 116 ± 22% in the R-RL group (P < 0.01). Microcirculatory flow was higher in group GD-C in healthy colon. CONCLUSIONS: Goal-directed colloid fluid therapy significantly increased microcirculatory blood flow and tissue oxygen tension in healthy and injured colon compared to goal-directed or restricted crystalloid fluid therapy.

OriginalspracheEnglisch
ZeitschriftAnesthesiology
Jahrgang110
Ausgabenummer3
Seiten (von - bis)496-504
Seitenumfang9
ISSN0003-3022
DOIs
PublikationsstatusVeröffentlicht - 03.2009

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