Geschlechtsspezifische Unterschiede und Outcome bei älteren Patienten nach überlebtem präklinischem Herzstillstand

Toni Pätz*, Katharina Stelzig, Rüdiger Pfeifer, Holger Thiele, Hans Jörg Busch, Thomas Stiermaier, Ingo Eitel, Sebastian Wolfrum

*Korrespondierende/r Autor/-in für diese Arbeit
2 Zitate (Scopus)

Abstract

Background: Little is known about sex differences in elderly patients after out-of-hospital cardiac arrest (OHCA) with return of spontaneous circulation (ROSC) and subsequent target temperature management (TTM). Therefore, this study was designed to evaluate sex-specific differences in survival and neurological outcome in elderly patients at 28-day and 180-day follow-up. Methods: A total of 468 nontraumatic OHCA survivors with preclinical ROSC and an age of ≥ 65 years were included in this study. Sex-specific differences in survival and a favorable neurological outcome according to the cerebral performance category (CPC) score were evaluated as clinical endpoints. Results: Of all participants included, 70.7% were men and 29.3% women. Women were significantly older (p = 0.011) and were more likely to have a nonshockable rhythm (p = 0.001) than men. Evaluation of survival rate and favorable neurological outcome by sex category showed no significant differences at 28-day and 180-day follow-up. In multiple stepwise logistic regression analysis, age (odds ratio 0.932 [95% confidence interval 0.891–0.951], p = 0.002) and time of hypoxia (0.899 [0.850–0.951], p < 0.001) proved to be independent predictors of survival only in male patients, whereas an initial shockable rhythm (4.325 [1.309–14.291], p = 0.016) was associated with 180-day survival in female patients. The majority of patients (93.7%) remained in the same CPC category when comparing 28-day and 180-day follow-up. Conclusion: Our results show no significant sex-specific differences in survival or favorable neurological outcome in elderly patients after having survived OHCA, but sex-specific predictors for 180-day survival. Moreover, the neurological assessment 28 days after the index event also seems to provide a valid indication for the further prognosis in elderly patients.

Titel in ÜbersetzungSex-specific differences and outcome in elderly patients after survived out-of-hospital cardiac arrest
OriginalspracheDeutsch
ZeitschriftMedizinische Klinik - Intensivmedizin und Notfallmedizin
Jahrgang117
Ausgabenummer8
Seiten (von - bis)630-638
Seitenumfang9
ISSN2193-6218
DOIs
PublikationsstatusVeröffentlicht - 11.2022

Strategische Forschungsbereiche und Zentren

  • Zentren: Universitäres Herzzentrum Lübeck (UHZL)

DFG-Fachsystematik

  • 205-12 Kardiologie, Angiologie

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