Genome-wide scan for Parkinson's disease: The GenePD study

A. L. DeStefano; L. I. Golbe; M. H. Mark; A. M. Lazzarini; N. E. Maher; M. Saint-Hilaire; R. G. Feldman; M. Guttman; R. L. Watts; O. Suchowersky; A. L. Lafontaine; N. Labelle; M. F. Lew; C. H. Waters; J. H. Growdon; C. Singer; L. J. Currie; G. F. Wooten; P. Vieregge; P. P. Pramstaller; C. Klein; J. P. Hubble; M. Stacy; E. Montgomery; M. E. MacDonald; J. F. Gusella; R. H. Myers

doi:10.1212/WNL.57.6.1124

Genome-wide scan for Parkinson's disease: The GenePD study

A. L. DeStefano, L. I. Golbe, M. H. Mark, A. M. Lazzarini, N. E. Maher, M. Saint-Hilaire, R. G. Feldman, M. Guttman, R. L. Watts, O. Suchowersky, A. L. Lafontaine, N. Labelle, M. F. Lew, C. H. Waters, J. H. Growdon, C. Singer, L. J. Currie, G. F. Wooten, P. Vieregge, P. P. PramstallerC. Klein, J. P. Hubble, M. Stacy, E. Montgomery, M. E. MacDonald, J. F. Gusella, R. H. Myers^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Neurogenetik

77 Zitate (Scopus)

Abstract

A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.

Originalsprache	Englisch
Zeitschrift	Neurology
Jahrgang	57
Ausgabenummer	6
Seiten (von - bis)	1124-1126
Seitenumfang	3
ISSN	0028-3878
DOIs	https://doi.org/10.1212/WNL.57.6.1124
Publikationsstatus	Veröffentlicht - 25.09.2001

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10.1212/WNL.57.6.1124

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DeStefano, A. L., Golbe, L. I., Mark, M. H., Lazzarini, A. M., Maher, N. E., Saint-Hilaire, M., Feldman, R. G., Guttman, M., Watts, R. L., Suchowersky, O., Lafontaine, A. L., Labelle, N., Lew, M. F., Waters, C. H., Growdon, J. H., Singer, C., Currie, L. J., Wooten, G. F., Vieregge, P., ... Myers, R. H. (2001). Genome-wide scan for Parkinson's disease: The GenePD study. Neurology, 57(6), 1124-1126. https://doi.org/10.1212/WNL.57.6.1124

@article{57ad592ab85043bb9b7989be13c5ed36,

title = "Genome-wide scan for Parkinson's disease: The GenePD study",

abstract = "A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.",

author = "DeStefano, \{A. L.\} and Golbe, \{L. I.\} and Mark, \{M. H.\} and Lazzarini, \{A. M.\} and Maher, \{N. E.\} and M. Saint-Hilaire and Feldman, \{R. G.\} and M. Guttman and Watts, \{R. L.\} and O. Suchowersky and Lafontaine, \{A. L.\} and N. Labelle and Lew, \{M. F.\} and Waters, \{C. H.\} and Growdon, \{J. H.\} and C. Singer and Currie, \{L. J.\} and Wooten, \{G. F.\} and P. Vieregge and Pramstaller, \{P. P.\} and C. Klein and Hubble, \{J. P.\} and M. Stacy and E. Montgomery and MacDonald, \{M. E.\} and Gusella, \{J. F.\} and Myers, \{R. H.\}",

year = "2001",

month = sep,

day = "25",

doi = "10.1212/WNL.57.6.1124",

language = "English",

volume = "57",

pages = "1124--1126",

journal = "Neurology",

issn = "0028-3878",

publisher = "American Medical Association",

number = "6",

}

DeStefano, AL, Golbe, LI, Mark, MH, Lazzarini, AM, Maher, NE, Saint-Hilaire, M, Feldman, RG, Guttman, M, Watts, RL, Suchowersky, O, Lafontaine, AL, Labelle, N, Lew, MF, Waters, CH, Growdon, JH, Singer, C, Currie, LJ, Wooten, GF, Vieregge, P, Pramstaller, PP, Klein, C, Hubble, JP, Stacy, M, Montgomery, E, MacDonald, ME, Gusella, JF & Myers, RH 2001, 'Genome-wide scan for Parkinson's disease: The GenePD study', Neurology, Jg. 57, Nr. 6, S. 1124-1126. https://doi.org/10.1212/WNL.57.6.1124

TY - JOUR

T1 - Genome-wide scan for Parkinson's disease: The GenePD study

AU - DeStefano, A. L.

AU - Golbe, L. I.

AU - Mark, M. H.

AU - Lazzarini, A. M.

AU - Maher, N. E.

AU - Saint-Hilaire, M.

AU - Feldman, R. G.

AU - Guttman, M.

AU - Watts, R. L.

AU - Suchowersky, O.

AU - Lafontaine, A. L.

AU - Labelle, N.

AU - Lew, M. F.

AU - Waters, C. H.

AU - Growdon, J. H.

AU - Singer, C.

AU - Currie, L. J.

AU - Wooten, G. F.

AU - Vieregge, P.

AU - Pramstaller, P. P.

AU - Klein, C.

AU - Hubble, J. P.

AU - Stacy, M.

AU - Montgomery, E.

AU - MacDonald, M. E.

AU - Gusella, J. F.

AU - Myers, R. H.

PY - 2001/9/25

Y1 - 2001/9/25

N2 - A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.

AB - A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.

UR - https://www.scopus.com/pages/publications/0035949797

U2 - 10.1212/WNL.57.6.1124

DO - 10.1212/WNL.57.6.1124

M3 - Journal articles

AN - SCOPUS:0035949797

SN - 0028-3878

VL - 57

SP - 1124

EP - 1126

JO - Neurology

JF - Neurology

IS - 6

ER -

Genome-wide scan for Parkinson's disease: The GenePD study

Abstract

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