Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

David Alexandre Trégouët; Inke R. König; Jeanette Erdmann; Alexandru Munteanu; Peter S. Braund; Alistair S. Hall; Anika Großhennig; Patrick Linsel-Nitschke; Claire Perret; Maylis DeSuremain; Thomas Meitinger; Ben J. Wright; Michael Preuss; Anthony J. Balmforth; Stephen G. Ball; Christa Meisinger; Cécile Germain; Alun Evans; Dominique Arveiler; Gérald Luc; Jean Bernard Ruidavets; Caroline Morrison; Pim Van Der Harst; Stefan Schreiber; Katharina Neureuther; Arne Schäfer; Peter Bugert; Nour E. El Mokhtari; Jürgen Schrezenmeir; Klaus Stark; Diana Rubin; H. Erich Wichmann; Christian Hengstenberg; Willem Ouwehand; Andreas Ziegler; Laurence Tiret; John R. Thompson; Francois Cambien; Heribert Schunkert; Nilesh J. Samani

doi:10.1038/ng.314

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

David Alexandre Trégouët^*, Inke R. König, Jeanette Erdmann, Alexandru Munteanu, Peter S. Braund, Alistair S. Hall, Anika Großhennig, Patrick Linsel-Nitschke, Claire Perret, Maylis DeSuremain, Thomas Meitinger, Ben J. Wright, Michael Preuss, Anthony J. Balmforth, Stephen G. Ball, Christa Meisinger, Cécile Germain, Alun Evans, Dominique Arveiler, Gérald LucJean Bernard Ruidavets, Caroline Morrison, Pim Van Der Harst, Stefan Schreiber, Katharina Neureuther, Arne Schäfer, Peter Bugert, Nour E. El Mokhtari, Jürgen Schrezenmeir, Klaus Stark, Diana Rubin, H. Erich Wichmann, Christian Hengstenberg, Willem Ouwehand, Andreas Ziegler, Laurence Tiret, John R. Thompson, Francois Cambien, Heribert Schunkert, Nilesh J. Samani

^*Korrespondierende/r Autor/-in für diese Arbeit

412 Zitate (Scopus)

Abstract

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

Originalsprache	Englisch
Zeitschrift	Nature Genetics
Jahrgang	41
Ausgabenummer	3
Seiten (von - bis)	283-285
Seitenumfang	3
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.314
Publikationsstatus	Veröffentlicht - 01.03.2009

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The WTCCC Study was funded by the Wellcome Trust. Recruitment of cases for the WTCCC Study was carried out by the British Heart Foundation (BHF) Family Heart Study Research Group and supported by the BHF and the UK Medical Research Council. We also acknowledge support of the Wellcome Trust Functional Genomics Initiative in Cardiovascular Genetics. The German Study was supported by the Deutsche Forschungsgemeinschaft, the German Federal Ministry of Education and Research in the context of the German National Genome Research Network (NGFN-2 and NGFN-plus). The KORA research platform (KORA, Cooperative Research in the Region of Augsburg) was initiated and financed by the GSF-National Research Centre for Environment and Health, which is funded by the German Federal Ministry of Education and Research and of the State of Bavaria. This work has also been partially supported by the EGEE-II project funded by the European Union INFSO-RI-031688. N.J.S. is supported by a Chair funded by the BHF. The main sponsor of the current analysis is the EU funded integrated project ‘Cardiogenics’ (LSHM-CT-2006-037593). This work was designed by D.-A.T., L.T., F.C., H.S. and N.J.S. Statistical analyses were carried out by D.-A.T., I.R.K., A.G., M.P., P.H., A.Z. and J.R.T., J.E., P.S.B., C.P., M.D., P.B. and W.O. supervised and/or participated in the genetic laboratory analyses. A.M. developed the computing grid program under the supervision of D.-A.T. and C.G. Case collections were coordinated by P.S.B., A.S.H., B.J.W., A.J.B., S.G.B., W.O., J.R.T., N.J.S. (WTCCC), J.E., T.M., H.-E.W., C. Meisinger, C.H., K.N., K.S., J.S., D.R. (GerMIFS), S.S., A.S., N.E.E.-M. (PopGene), J.E., P.L.-N. (Angio-Luebeck), A.E., D.A., G.L., J.-B.R., and C. Morrison (ECTIM). D.A.T., L.T., F.C., H.S. and N.J.S. drafted the manuscript with substantial contributions from I.R.K., J.E., A.Z.

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Trégouët, D. A., König, I. R., Erdmann, J., Munteanu, A., Braund, P. S., Hall, A. S., Großhennig, A., Linsel-Nitschke, P., Perret, C., DeSuremain, M., Meitinger, T., Wright, B. J., Preuss, M., Balmforth, A. J., Ball, S. G., Meisinger, C., Germain, C., Evans, A., Arveiler, D., ... Samani, N. J. (2009). Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nature Genetics, 41(3), 283-285. https://doi.org/10.1038/ng.314

@article{0ca6da3a725c4adfa86667fcd17014fe,

title = "Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease",

abstract = "We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.",

author = "Tr{\'e}gou{\"e}t, \{David Alexandre\} and K{\"o}nig, \{Inke R.\} and Jeanette Erdmann and Alexandru Munteanu and Braund, \{Peter S.\} and Hall, \{Alistair S.\} and Anika Gro{\ss}hennig and Patrick Linsel-Nitschke and Claire Perret and Maylis DeSuremain and Thomas Meitinger and Wright, \{Ben J.\} and Michael Preuss and Balmforth, \{Anthony J.\} and Ball, \{Stephen G.\} and Christa Meisinger and C{\'e}cile Germain and Alun Evans and Dominique Arveiler and G{\'e}rald Luc and Ruidavets, \{Jean Bernard\} and Caroline Morrison and \{Van Der Harst\}, Pim and Stefan Schreiber and Katharina Neureuther and Arne Sch{\"a}fer and Peter Bugert and \{El Mokhtari\}, \{Nour E.\} and J{\"u}rgen Schrezenmeir and Klaus Stark and Diana Rubin and Wichmann, \{H. Erich\} and Christian Hengstenberg and Willem Ouwehand and Andreas Ziegler and Laurence Tiret and Thompson, \{John R.\} and Francois Cambien and Heribert Schunkert and Samani, \{Nilesh J.\}",

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doi = "10.1038/ng.314",

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Trégouët, DA, König, IR, Erdmann, J, Munteanu, A, Braund, PS, Hall, AS, Großhennig, A, Linsel-Nitschke, P, Perret, C, DeSuremain, M, Meitinger, T, Wright, BJ, Preuss, M, Balmforth, AJ, Ball, SG, Meisinger, C, Germain, C, Evans, A, Arveiler, D, Luc, G, Ruidavets, JB, Morrison, C, Van Der Harst, P, Schreiber, S, Neureuther, K, Schäfer, A, Bugert, P, El Mokhtari, NE, Schrezenmeir, J, Stark, K, Rubin, D, Wichmann, HE, Hengstenberg, C, Ouwehand, W, Ziegler, A, Tiret, L, Thompson, JR, Cambien, F, Schunkert, H & Samani, NJ 2009, 'Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease', Nature Genetics, Jg. 41, Nr. 3, S. 283-285. https://doi.org/10.1038/ng.314

TY - JOUR

T1 - Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

AU - Trégouët, David Alexandre

AU - König, Inke R.

AU - Erdmann, Jeanette

AU - Munteanu, Alexandru

AU - Braund, Peter S.

AU - Hall, Alistair S.

AU - Großhennig, Anika

AU - Linsel-Nitschke, Patrick

AU - Perret, Claire

AU - DeSuremain, Maylis

AU - Meitinger, Thomas

AU - Wright, Ben J.

AU - Preuss, Michael

AU - Balmforth, Anthony J.

AU - Ball, Stephen G.

AU - Meisinger, Christa

AU - Germain, Cécile

AU - Evans, Alun

AU - Arveiler, Dominique

AU - Luc, Gérald

AU - Ruidavets, Jean Bernard

AU - Morrison, Caroline

AU - Van Der Harst, Pim

AU - Schreiber, Stefan

AU - Neureuther, Katharina

AU - Schäfer, Arne

AU - Bugert, Peter

AU - El Mokhtari, Nour E.

AU - Schrezenmeir, Jürgen

AU - Stark, Klaus

AU - Rubin, Diana

AU - Wichmann, H. Erich

AU - Hengstenberg, Christian

AU - Ouwehand, Willem

AU - Ziegler, Andreas

AU - Tiret, Laurence

AU - Thompson, John R.

AU - Cambien, Francois

AU - Schunkert, Heribert

AU - Samani, Nilesh J.

PY - 2009/3/1

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N2 - We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

AB - We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

UR - https://www.scopus.com/pages/publications/61349137526

U2 - 10.1038/ng.314

DO - 10.1038/ng.314

M3 - Journal articles

C2 - 19198611

AN - SCOPUS:61349137526

SN - 1061-4036

VL - 41

SP - 283

EP - 285

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

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