Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - A sub-analysis of the RIPHeart-Study

Sabine Westphal; Christian Stoppe; Matthias Gruenewald; Berthold Bein; Jochen Renner; Jochen Cremer; Mark Coburn; Gereon Schaelte; Andreas Boening; Bernd Niemann; Frank Kletzin; Jan Roesner; Ulrich Strouhal; Christian Reyher; Rita Laufenberg-Feldmann; Marion Ferner; Ivo F. Brandes; Martin Bauer; Andreas Kortgen; Sebastian N. Stehr; Maria Wittmann; Georg Baumgarten; Rafael Struck; Tanja Meyer-Treschan; Peter Kienbaum; Matthias Heringlake; Julika Schoen; Michael Sander; Sascha Treskatsch; Thorsten Smul; Ewa Wolwender; Thomas Schilling; Frauke Degenhardt; Andre Franke; Soeren Mucha; Lukas Tittmann; Madeline Kohlhaas; Georg Fuernau; Oana Brosteanu; Dirk Hasenclever; Kai Zacharowski; Patrick Meybohm

doi:10.1186/s12872-019-1002-x

Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - A sub-analysis of the RIPHeart-Study

Sabine Westphal, Christian Stoppe, Matthias Gruenewald, Berthold Bein, Jochen Renner, Jochen Cremer, Mark Coburn, Gereon Schaelte, Andreas Boening, Bernd Niemann, Frank Kletzin, Jan Roesner, Ulrich Strouhal, Christian Reyher, Rita Laufenberg-Feldmann, Marion Ferner, Ivo F. Brandes, Martin Bauer, Andreas Kortgen, Sebastian N. StehrMaria Wittmann, Georg Baumgarten, Rafael Struck, Tanja Meyer-Treschan, Peter Kienbaum, Matthias Heringlake, Julika Schoen, Michael Sander, Sascha Treskatsch, Thorsten Smul, Ewa Wolwender, Thomas Schilling, Frauke Degenhardt, Andre Franke, Soeren Mucha, Lukas Tittmann, Madeline Kohlhaas, Georg Fuernau, Oana Brosteanu, Dirk Hasenclever, Kai Zacharowski, Patrick Meybohm^*

^*Korrespondierende/r Autor/-in für diese Arbeit

23 Zitate (Scopus)

Abstract

BACKGROUND: The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.

METHODS: We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.

RESULTS: A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10 - 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10 - 5 from the GWAS.

CONCLUSIONS: We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.

TRIAL REGISTRATION: The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.

Originalsprache	Englisch
Aufsatznummer	1002
Zeitschrift	BMC cardiovascular disorders
Jahrgang	19
Ausgabenummer	1
Seiten (von - bis)	26
ISSN	1471-2261
DOIs	https://doi.org/10.1186/s12872-019-1002-x
Publikationsstatus	Veröffentlicht - 24.01.2019

Fördermittel

This work was supported by a grant (ME 3559/1–1) from the German Research Foundation with funds for staff and required gene chips for analysis. The funding had no impact on the design of the study and the collection and the scientific analysis and interpretation of data as well as in writing the manuscript.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

Dokumente

10.1186/s12872-019-1002-x

Weitere Links

Fingerprint

Untersuchen Sie die Forschungsthemen von „Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - A sub-analysis of the RIPHeart-Study“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren

Westphal, S., Stoppe, C., Gruenewald, M., Bein, B., Renner, J., Cremer, J., Coburn, M., Schaelte, G., Boening, A., Niemann, B., Kletzin, F., Roesner, J., Strouhal, U., Reyher, C., Laufenberg-Feldmann, R., Ferner, M., Brandes, I. F., Bauer, M., Kortgen, A., ... Meybohm, P. (2019). Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - A sub-analysis of the RIPHeart-Study. BMC cardiovascular disorders, 19(1), 26. Artikel 1002. https://doi.org/10.1186/s12872-019-1002-x

@article{79668c976a67428ab6aed8ef317afd85,

title = "Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - A sub-analysis of the RIPHeart-Study",

abstract = "BACKGROUND: The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.METHODS: We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.RESULTS: A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10 - 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10 - 5 from the GWAS. CONCLUSIONS: We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.TRIAL REGISTRATION: The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.",

author = "Sabine Westphal and Christian Stoppe and Matthias Gruenewald and Berthold Bein and Jochen Renner and Jochen Cremer and Mark Coburn and Gereon Schaelte and Andreas Boening and Bernd Niemann and Frank Kletzin and Jan Roesner and Ulrich Strouhal and Christian Reyher and Rita Laufenberg-Feldmann and Marion Ferner and Brandes, \{Ivo F.\} and Martin Bauer and Andreas Kortgen and Stehr, \{Sebastian N.\} and Maria Wittmann and Georg Baumgarten and Rafael Struck and Tanja Meyer-Treschan and Peter Kienbaum and Matthias Heringlake and Julika Schoen and Michael Sander and Sascha Treskatsch and Thorsten Smul and Ewa Wolwender and Thomas Schilling and Frauke Degenhardt and Andre Franke and Soeren Mucha and Lukas Tittmann and Madeline Kohlhaas and Georg Fuernau and Oana Brosteanu and Dirk Hasenclever and Kai Zacharowski and Patrick Meybohm",

year = "2019",

month = jan,

day = "24",

doi = "10.1186/s12872-019-1002-x",

language = "English",

volume = "19",

pages = "26",

journal = "BMC cardiovascular disorders",

issn = "1471-2261",

number = "1",

}

Westphal, S, Stoppe, C, Gruenewald, M, Bein, B, Renner, J, Cremer, J, Coburn, M, Schaelte, G, Boening, A, Niemann, B, Kletzin, F, Roesner, J, Strouhal, U, Reyher, C, Laufenberg-Feldmann, R, Ferner, M, Brandes, IF, Bauer, M, Kortgen, A, Stehr, SN, Wittmann, M, Baumgarten, G, Struck, R, Meyer-Treschan, T, Kienbaum, P, Heringlake, M, Schoen, J, Sander, M, Treskatsch, S, Smul, T, Wolwender, E, Schilling, T, Degenhardt, F, Franke, A, Mucha, S, Tittmann, L, Kohlhaas, M, Fuernau, G, Brosteanu, O, Hasenclever, D, Zacharowski, K & Meybohm, P 2019, 'Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - A sub-analysis of the RIPHeart-Study', BMC cardiovascular disorders, Jg. 19, Nr. 1, 1002, S. 26. https://doi.org/10.1186/s12872-019-1002-x

Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - A sub-analysis of the RIPHeart-Study. / Westphal, Sabine; Stoppe, Christian; Gruenewald, Matthias et al.
in: BMC cardiovascular disorders, Jahrgang 19, Nr. 1, 1002, 24.01.2019, S. 26.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - A sub-analysis of the RIPHeart-Study

AU - Westphal, Sabine

AU - Stoppe, Christian

AU - Gruenewald, Matthias

AU - Bein, Berthold

AU - Renner, Jochen

AU - Cremer, Jochen

AU - Coburn, Mark

AU - Schaelte, Gereon

AU - Boening, Andreas

AU - Niemann, Bernd

AU - Kletzin, Frank

AU - Roesner, Jan

AU - Strouhal, Ulrich

AU - Reyher, Christian

AU - Laufenberg-Feldmann, Rita

AU - Ferner, Marion

AU - Brandes, Ivo F.

AU - Bauer, Martin

AU - Kortgen, Andreas

AU - Stehr, Sebastian N.

AU - Wittmann, Maria

AU - Baumgarten, Georg

AU - Struck, Rafael

AU - Meyer-Treschan, Tanja

AU - Kienbaum, Peter

AU - Heringlake, Matthias

AU - Schoen, Julika

AU - Sander, Michael

AU - Treskatsch, Sascha

AU - Smul, Thorsten

AU - Wolwender, Ewa

AU - Schilling, Thomas

AU - Degenhardt, Frauke

AU - Franke, Andre

AU - Mucha, Soeren

AU - Tittmann, Lukas

AU - Kohlhaas, Madeline

AU - Fuernau, Georg

AU - Brosteanu, Oana

AU - Hasenclever, Dirk

AU - Zacharowski, Kai

AU - Meybohm, Patrick

PY - 2019/1/24

Y1 - 2019/1/24

N2 - BACKGROUND: The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.METHODS: We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.RESULTS: A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10 - 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10 - 5 from the GWAS. CONCLUSIONS: We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.TRIAL REGISTRATION: The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.

AB - BACKGROUND: The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.METHODS: We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.RESULTS: A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10 - 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10 - 5 from the GWAS. CONCLUSIONS: We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.TRIAL REGISTRATION: The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.

UR - https://www.scopus.com/pages/publications/85060529420

UR - http://www.mendeley.com/research/genomewide-association-study-myocardial-infarction-atrial-fibrillation-acute-stroke-acute-kidney-inj

U2 - 10.1186/s12872-019-1002-x

DO - 10.1186/s12872-019-1002-x

M3 - Journal articles

C2 - 30678657

AN - SCOPUS:85060529420

SN - 1471-2261

VL - 19

SP - 26

JO - BMC cardiovascular disorders

JF - BMC cardiovascular disorders

IS - 1

M1 - 1002

ER -