Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

Andre Franke; Tobias Balschun; Christian Sina; David Ellinghaus; Robert Häsler; Gabriele Mayr; Mario Albrecht; Michael Wittig; Eva Buchert; Susanna Nikolaus; Christian Gieger; H. Erich Wichmann; Jurgita Sventoraityte; Limas Kupcinskas; Clive M. Onnie; Maria Gazouli; Nicholas P. Anagnou; David Strachan; Wendy L. McArdle; Christopher G. Mathew; Paul Rutgeerts; Séverine Vermeire; Morten H. Vatn; Michael Krawczak; Philip Rosenstiel; Tom H. Karlsen; Stefan Schreiber

doi:10.1038/ng.553

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

Andre Franke^*, Tobias Balschun, Christian Sina, David Ellinghaus, Robert Häsler, Gabriele Mayr, Mario Albrecht, Michael Wittig, Eva Buchert, Susanna Nikolaus, Christian Gieger, H. Erich Wichmann, Jurgita Sventoraityte, Limas Kupcinskas, Clive M. Onnie, Maria Gazouli, Nicholas P. Anagnou, David Strachan, Wendy L. McArdle, Christopher G. MathewPaul Rutgeerts, Séverine Vermeire, Morten H. Vatn, Michael Krawczak, Philip Rosenstiel, Tom H. Karlsen, Stefan Schreiber

^*Korrespondierende/r Autor/-in für diese Arbeit

Medizinische Klinik I

182 Zitate (Scopus)

Abstract

We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P rs7809799 = 8.81 × 10 ^-11 and P _rs5771069 = 4.21 × 10 ^-8, respectively).

Originalsprache	Englisch
Zeitschrift	Nature Genetics
Jahrgang	42
Ausgabenummer	4
Seiten (von - bis)	292-294
Seitenumfang	3
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.553
Publikationsstatus	Veröffentlicht - 01.04.2010

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We thank all individuals with UC and CD studied here, their families and physicians for their cooperation. We acknowledge the cooperation of the German Crohn and Colitis Foundation (Deutsche Morbus Crohn und Colitis Vereingung e.V.), the German Ministry of Education and Research (BMBF) competence network “IBD” and the contributing gastroenterologists. We thank E. Melum and K. Holm for discussion and support; T. Wesse, T. Henke, C. Fürstenau, S. Ehlers and R. Vogler for expert technical help; T. Wienker and M. Steffens (Institut für Medizinische Biometrie, Informatik und Epidemiologie, University of Bonn) for performing the quality control of the GWAS datasets; B.A. Lie and the Norwegian Bone Marrow Donor Registry at Rikshospitalet University Hospital, Oslo, for contributing the healthy Norwegian control population; and the following individuals for their invaluable participation in the collection of the Baltic (Lithuanian and Latvian) patient panel: G. Kiudelis, L. Jonaitis, A. Zvirbliene, G. Denapiene, A. Irnius, J. Valantinas, V. Svalbonas, D. Krukas, G. Simulionis, Z. Sukys, M. Leja and A. Derovs. This study was supported by the BMBF through the National Genome Research Network (NGFN), the PopGen Biobank and the Cooperative Research in the Region of Augsburg (KORA) research platform. KORA was initiated and financed by the Helmholtz Zentrum München–National Research Center for Environmental Health, which is funded by the German Federal Ministry of Education, Science, Research and Technology and by the State of Bavaria and the Munich Center of Health Sciences (MC Health) as part of the LMUinnovativ initiative. The project received infrastructure support through the Deutsche Forschungsgemeinschaft clusters of excellence Multimodal Computing and Interaction, Future Ocean, and Inflammation and Interfaces. We acknowledge use of DNA from the 1958 British Birth Cohort collection (courtesy of R. Jones, S. Ring, W. McArdle and M. Pembrey), funded by the UK Medical Research Council (grant G0000934) and the Wellcome Trust (grant 068545/Z/02). C.G.M. and C.M.O. were supported by The Wellcome Trust and Core (UK).

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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2.21-05 Immunologie
2.22-15 Gastroenterologie

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10.1038/ng.553

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EXC 306: Entzündungen an Grenzflächen
Schreiber, S. (Sprecher*in), Bosch, T. C. G. (Beteiligte*r Wissenschaftler*in), Ehlers, S. (Beteiligte*r Wissenschaftler*in), Erdmann, J. (Beteiligte*r Wissenschaftler*in), Ernst, R. (Beteiligte*r Wissenschaftler*in), Franke, A. (Beteiligte*r Wissenschaftler*in), Gross, W. (Beteiligte*r Wissenschaftler*in), Hilgenfeld, R. (Beteiligte*r Wissenschaftler*in), Kabelitz, D. (Beteiligte*r Wissenschaftler*in), Köhl, J. (Beteiligte*r Wissenschaftler*in), Manz, R. (Beteiligte*r Wissenschaftler*in), Nebel, A. (Beteiligte*r Wissenschaftler*in), Niemann, S. (Beteiligte*r Wissenschaftler*in), Rabe, K. F. (Beteiligte*r Wissenschaftler*in), Rimbach, G. (Beteiligte*r Wissenschaftler*in), Rose-John, S. (Beteiligte*r Wissenschaftler*in), Rosenstiel, P. C. (Beteiligte*r Wissenschaftler*in), Saftig, P. (Beteiligte*r Wissenschaftler*in), Schaible, U. (Beteiligte*r Wissenschaftler*in), Schröder, J.-M. (Beteiligte*r Wissenschaftler*in), Schütze, S. (Beteiligte*r Wissenschaftler*in), Siebert, R. (Beteiligte*r Wissenschaftler*in), Tautz, D. (Beteiligte*r Wissenschaftler*in), Weidinger, S. (Beteiligte*r Wissenschaftler*in) & Zillikens, D. (Beteiligte*r Wissenschaftler*in)
01.01.07 → 31.12.18
Projekt: DFG Verbundprojekte › Exzellenzcluster

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Franke, A., Balschun, T., Sina, C., Ellinghaus, D., Häsler, R., Mayr, G., Albrecht, M., Wittig, M., Buchert, E., Nikolaus, S., Gieger, C., Wichmann, H. E., Sventoraityte, J., Kupcinskas, L., Onnie, C. M., Gazouli, M., Anagnou, N. P., Strachan, D., McArdle, W. L., ... Schreiber, S. (2010). Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nature Genetics, 42(4), 292-294. https://doi.org/10.1038/ng.553

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title = "Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)",

abstract = "We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P rs7809799 = 8.81 × 10 -11 and P rs5771069 = 4.21 × 10 -8, respectively).",

author = "Andre Franke and Tobias Balschun and Christian Sina and David Ellinghaus and Robert H{\"a}sler and Gabriele Mayr and Mario Albrecht and Michael Wittig and Eva Buchert and Susanna Nikolaus and Christian Gieger and Wichmann, \{H. Erich\} and Jurgita Sventoraityte and Limas Kupcinskas and Onnie, \{Clive M.\} and Maria Gazouli and Anagnou, \{Nicholas P.\} and David Strachan and McArdle, \{Wendy L.\} and Mathew, \{Christopher G.\} and Paul Rutgeerts and S{\'e}verine Vermeire and Vatn, \{Morten H.\} and Michael Krawczak and Philip Rosenstiel and Karlsen, \{Tom H.\} and Stefan Schreiber",

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Franke, A, Balschun, T, Sina, C, Ellinghaus, D, Häsler, R, Mayr, G, Albrecht, M, Wittig, M, Buchert, E, Nikolaus, S, Gieger, C, Wichmann, HE, Sventoraityte, J, Kupcinskas, L, Onnie, CM, Gazouli, M, Anagnou, NP, Strachan, D, McArdle, WL, Mathew, CG, Rutgeerts, P, Vermeire, S, Vatn, MH, Krawczak, M, Rosenstiel, P, Karlsen, TH & Schreiber, S 2010, 'Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)', Nature Genetics, Jg. 42, Nr. 4, S. 292-294. https://doi.org/10.1038/ng.553

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AU - Franke, Andre

AU - Balschun, Tobias

AU - Sina, Christian

AU - Ellinghaus, David

AU - Häsler, Robert

AU - Mayr, Gabriele

AU - Albrecht, Mario

AU - Wittig, Michael

AU - Buchert, Eva

AU - Nikolaus, Susanna

AU - Gieger, Christian

AU - Wichmann, H. Erich

AU - Sventoraityte, Jurgita

AU - Kupcinskas, Limas

AU - Onnie, Clive M.

AU - Gazouli, Maria

AU - Anagnou, Nicholas P.

AU - Strachan, David

AU - McArdle, Wendy L.

AU - Mathew, Christopher G.

AU - Rutgeerts, Paul

AU - Vermeire, Séverine

AU - Vatn, Morten H.

AU - Krawczak, Michael

AU - Rosenstiel, Philip

AU - Karlsen, Tom H.

AU - Schreiber, Stefan

PY - 2010/4/1

Y1 - 2010/4/1

N2 - We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P rs7809799 = 8.81 × 10 -11 and P rs5771069 = 4.21 × 10 -8, respectively).

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JO - Nature Genetics

JF - Nature Genetics

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ER -

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

Abstract

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