TY - JOUR
T1 - Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
AU - Franke, Andre
AU - Balschun, Tobias
AU - Sina, Christian
AU - Ellinghaus, David
AU - Häsler, Robert
AU - Mayr, Gabriele
AU - Albrecht, Mario
AU - Wittig, Michael
AU - Buchert, Eva
AU - Nikolaus, Susanna
AU - Gieger, Christian
AU - Wichmann, H. Erich
AU - Sventoraityte, Jurgita
AU - Kupcinskas, Limas
AU - Onnie, Clive M.
AU - Gazouli, Maria
AU - Anagnou, Nicholas P.
AU - Strachan, David
AU - McArdle, Wendy L.
AU - Mathew, Christopher G.
AU - Rutgeerts, Paul
AU - Vermeire, Séverine
AU - Vatn, Morten H.
AU - Krawczak, Michael
AU - Rosenstiel, Philip
AU - Karlsen, Tom H.
AU - Schreiber, Stefan
PY - 2010/4/1
Y1 - 2010/4/1
N2 - We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P rs7809799 = 8.81 × 10 -11 and P rs5771069 = 4.21 × 10 -8, respectively).
AB - We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P rs7809799 = 8.81 × 10 -11 and P rs5771069 = 4.21 × 10 -8, respectively).
UR - http://www.scopus.com/inward/record.url?scp=77950296637&partnerID=8YFLogxK
U2 - 10.1038/ng.553
DO - 10.1038/ng.553
M3 - Journal articles
C2 - 20228798
AN - SCOPUS:77950296637
SN - 1061-4036
VL - 42
SP - 292
EP - 294
JO - Nature Genetics
JF - Nature Genetics
IS - 4
ER -