Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee*

doi:10.1161/CIRCGEN.119.002769

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee*

9 Zitate (Scopus)

Abstract

BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D).

METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D).

RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background.

CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.

Originalsprache	Englisch
Zeitschrift	Circulation. Genomic and precision medicine
Jahrgang	13
Ausgabenummer	6
Seiten (von - bis)	e002769
DOIs	https://doi.org/10.1161/CIRCGEN.119.002769
Publikationsstatus	Veröffentlicht - 12.2020
Extern publiziert	Ja

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Querschnittsbereich: Medizinische Genetik
Zentren: Universitäres Herzzentrum Lübeck (UHZL)

DFG-Fachsystematik

2.22-17 Endokrinologie, Diabetologie, Metabolismus

Dokumente

10.1161/CIRCGEN.119.002769

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@article{380ba97a19ad44d4b5fe34b1e954c6c2,

title = "Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus",

abstract = "BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D).METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D).RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background.CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.",

author = "\{SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee*\} and \{van Zuydam\}, \{Natalie R\} and Claes Ladenvall and Voight, \{Benjamin F\} and Strawbridge, \{Rona J\} and Juan Fernandez-Tajes and Rayner, \{N William\} and Robertson, \{Neil R\} and Anubha Mahajan and Efthymia Vlachopoulou and Anuj Goel and Kleber, \{Marcus E\} and Nelson, \{Christopher P\} and Kwee, \{Lydia Coulter\} and T{\~o}nu Esko and Evelin Mihailov and Reedik M{\"a}gi and Lili Milani and Krista Fischer and Stavroula Kanoni and Jitender Kumar and Ci Song and Hartiala, \{Jaana A\} and Pedersen, \{Nancy L\} and Markus Perola and Christian Gieger and Annette Peters and Liming Qu and Willems, \{Sara M\} and Doney, \{Alex S F\} and Morris, \{Andrew D\} and Yan Zheng and Giorgio Sesti and Hu, \{Frank B\} and Lu Qi and Markku Laakso and Unnur Thorsteinsdottir and Harald Grallert and \{van Duijn\}, Cornelia and Reilly, \{Muredach P\} and Erik Ingelsson and Panos Deloukas and Sek Kathiresan and Andres Metspalu and Shah, \{Svati H\} and Juha Sinisalo and Veikko Salomaa and Anders Hamsten and Samani, \{Nilesh J\} and Winfried M{\"a}rz and Hazen, \{Stanley L\}",

year = "2020",

month = dec,

doi = "10.1161/CIRCGEN.119.002769",

language = "English",

volume = "13",

pages = "e002769",

journal = "Circulation. Genomic and precision medicine",

issn = "2574-8300",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

AU - SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee

AU - van Zuydam, Natalie R

AU - Ladenvall, Claes

AU - Voight, Benjamin F

AU - Strawbridge, Rona J

AU - Fernandez-Tajes, Juan

AU - Rayner, N William

AU - Robertson, Neil R

AU - Mahajan, Anubha

AU - Vlachopoulou, Efthymia

AU - Goel, Anuj

AU - Kleber, Marcus E

AU - Nelson, Christopher P

AU - Kwee, Lydia Coulter

AU - Esko, Tõnu

AU - Mihailov, Evelin

AU - Mägi, Reedik

AU - Milani, Lili

AU - Fischer, Krista

AU - Kanoni, Stavroula

AU - Kumar, Jitender

AU - Song, Ci

AU - Hartiala, Jaana A

AU - Pedersen, Nancy L

AU - Perola, Markus

AU - Gieger, Christian

AU - Peters, Annette

AU - Qu, Liming

AU - Willems, Sara M

AU - Doney, Alex S F

AU - Morris, Andrew D

AU - Zheng, Yan

AU - Sesti, Giorgio

AU - Hu, Frank B

AU - Qi, Lu

AU - Laakso, Markku

AU - Thorsteinsdottir, Unnur

AU - Grallert, Harald

AU - van Duijn, Cornelia

AU - Reilly, Muredach P

AU - Ingelsson, Erik

AU - Deloukas, Panos

AU - Kathiresan, Sek

AU - Metspalu, Andres

AU - Shah, Svati H

AU - Sinisalo, Juha

AU - Salomaa, Veikko

AU - Hamsten, Anders

AU - Samani, Nilesh J

AU - März, Winfried

AU - Hazen, Stanley L

PY - 2020/12

Y1 - 2020/12

N2 - BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D).METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D).RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background.CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.

AB - BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D).METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D).RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background.CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.

U2 - 10.1161/CIRCGEN.119.002769

DO - 10.1161/CIRCGEN.119.002769

M3 - Journal articles

C2 - 33321069

SN - 2574-8300

VL - 13

SP - e002769

JO - Circulation. Genomic and precision medicine

JF - Circulation. Genomic and precision medicine

IS - 6

ER -

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

Abstract

UN SDGs

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