Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients

Kati Tillack; Matthias Naegele; Cathleen Haueis; Sven Schippling; Klaus Peter Wandinger; Roland Martin; Mireia Sospedra

doi:10.1016/j.jneuroim.2013.05.004

Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients

Kati Tillack, Matthias Naegele, Cathleen Haueis, Sven Schippling, Klaus Peter Wandinger, Roland Martin, Mireia Sospedra^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Klinische Chemie

81 Zitate (Scopus)

Abstract

Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.

Originalsprache	Englisch
Zeitschrift	Journal of Neuroimmunology
Jahrgang	261
Ausgabenummer	1-2
Seiten (von - bis)	108-119
Seitenumfang	12
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2013.05.004
Publikationsstatus	Veröffentlicht - 15.08.2013

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We thank all the patients and healthy donors for their blood donations and the staff of the INiMS outpatient clinic and the staff of the Department for Transfusion Medicine, University Medical Centre Hamburg-Eppendorf for providing the samples. The INiMS was supported by the Gemeinnützige Hertie Stiftung, and this project was supported by the DFG grant SO 1029/1-1 . Appendix A

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title = "Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients",

abstract = "Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.",

author = "Kati Tillack and Matthias Naegele and Cathleen Haueis and Sven Schippling and Wandinger, \{Klaus Peter\} and Roland Martin and Mireia Sospedra",

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AU - Tillack, Kati

AU - Naegele, Matthias

AU - Haueis, Cathleen

AU - Schippling, Sven

AU - Wandinger, Klaus Peter

AU - Martin, Roland

AU - Sospedra, Mireia

PY - 2013/8/15

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N2 - Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.

AB - Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.

UR - https://www.scopus.com/pages/publications/84880834836

U2 - 10.1016/j.jneuroim.2013.05.004

DO - 10.1016/j.jneuroim.2013.05.004

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SN - 0165-5728

VL - 261

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EP - 119

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients

Abstract

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