Galectin-3 in cord blood of term and preterm infants

M. Demmert, K. Faust, M. K. Bohlmann, B. Tröger, W. Göpel, E. Herting, C. Härtel*

*Korrespondierende/r Autor/-in für diese Arbeit
9 Zitate (Scopus)

Abstract

In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of term and preterm neonates as well as galectin-3 levels in cord blood of term neonates after stimulation with the prevalent pathogen Streptococcusagalactiae. Cord blood samples were incubated for 24h and galectin-3 levels were assessed by enzyme-linked immunosorbent assay. There is a positive correlation between gestational age and galectin-3 levels in cord blood. Expression of galectin-3 is significantly higher in cord blood of small-for-gestational-age infants compared to appropriate-for-gestational-age infants. Stimulation with an invasive but not with a colonizing strain of S.agalactiae induced expression of galectin-3. Galectin-3 is expressed constitutively in cord blood of neonates and seems to play a role in the innate immunity of this population.

OriginalspracheEnglisch
ZeitschriftClinical and Experimental Immunology
Jahrgang167
Ausgabenummer2
Seiten (von - bis)246-251
Seitenumfang6
ISSN0009-9104
DOIs
PublikationsstatusVeröffentlicht - 01.02.2012

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