Foundations of circadian medicine

Achim Kramer; Tanja Lange; Claudia Spies; Anna Marie Finger; Daniela Berg; Henrik Oster

doi:10.1371/journal.pbio.3001567

Foundations of circadian medicine

Achim Kramer^*, Tanja Lange, Claudia Spies, Anna Marie Finger, Daniela Berg, Henrik Oster^*

^*Korrespondierende/r Autor/-in für diese Arbeit

73 Zitate (Scopus)

Abstract

The circadian clock is an evolutionarily highly conserved endogenous : timing program that structures physiology and behavior according to the time of day. Disruption of circadian rhythms is associated with many common pathologies. The emerging field of circadian medicine aims to exploit the mechanisms of circadian physiology and clock–disease interaction for clinical diagnosis, treatment, and prevention. In this Essay, we outline the principle approaches of circadian medicine, highlight the development of the field in selected areas, and point out open questions and challenges. Circadian medicine has unambiguous health benefits over standard care but is rarely utilized. It is time for clock biology to become an integrated part of translational research.

Originalsprache	Englisch
Aufsatznummer	e3001567
Zeitschrift	PLOS Biology
Jahrgang	20
Ausgabenummer	3
ISSN	1544-9173
DOIs	https://doi.org/10.1371/journal.pbio.3001567
Publikationsstatus	Veröffentlicht - 03.2022

Fördermittel

issuedpatents(PCT/EP2018/066771)andis preparingpatentsrelatedtobiomarkersfor detectingtheclock.Thisintellectualpropertyhas beenlicensedbyBodyClockGmbH,inwhichAKis ashareholder.AKreceiveseditor’shonorariafrom SpringerVerlagandGeorgThiemeVerlag.AKisa paidconsultanttoCircadianTherapeutics,and StanfordUniversity.AKismemberoftheEditorial BoardofPLoSBiology.Inaddition,heandhis researchprogramhavereceivedfinancial,material andtravelsupportfromarangeoffederal, industrial,legalandphilanthropicorganizationsin thepastandpresent.CSreportsgrantsfrom DeutscheForschungsgemeinschaft/German ResearchSociety,grantsfromDeutschesZentrum fu ¨r Luft-und Raumfahrte. V. (DLR)/German AerospaceCenter,grantsfromEinsteinStiftung Berlin/EinsteinFoundationBerlin,grantsfrom GemeinsamerBundesausschuss/FederalJoint Committee(G-BA),grantsfromInneruniversita ¨re Forschungsfo ¨rderung / InnerUniversity Grants, grantsfromProjekttra¨gerimDLR/Project ManagementAgency,grantsfromStifterverband/ Non-ProfitSocietyPromotingScienceand Education,grantsfromEuropeanSocietyof AnaesthesiologyandIntensiveCare,grantsfrom BaxterDeutschlandGmbH,grantsfrom CytosorbentsEuropeGmbH,grantsfromEdwards LifesciencesGermanyGmbH,grantsfrom FreseniusMedicalCare,grantsfromGru ¨nenthal GmbH,grantsfromMasimoEuropeLtd.,grants fromPfizerPharmaPFEGmbH,personalfeesfrom GeorgThiemeVerlag,grantsfromDr.F.Ko ¨hler ChemieGmbH,grantsfromSinteticaGmbH, grants from Stifterverband fu ¨r die deutsche Wissenschafte.V./PhilipsgrantsfromStiftung Charite ´,grantsfromAGUETTANTDeutschland GmbH,grantsfromAbbVieDeutschlandGmbH& Co.KG,grantsfromAmomedPharmaGmbH, grantsfromInTouchHealth,grantsfromCopra SystemGmbH,grantsfromCorrevioGmbH, grantsfromMax-Planck-Gesellschaftzur Fo ¨rderungderWissenschaftene.V.,grantsfrom Deutsche Gesellschaft fu ¨r Ana ¨sthesiologie& Intensivmedizin(DGAI,grantsfromStifterverband fu ¨r die deutscheWissenschaft Þ.V. / Metronic, grantsfromPhilipsElectronicsNederlandBV, grantsfromBMG,grantsfromBMBF,grantsfrom BMBF,grantsfromDra ¨gerwerkAG&Co.KGaA, outsidethesubmittedwork;Inaddition,CShasa patent102014215211.9licensed,apatent10 2018114364.8licensed,apatent102018110 275.5licensed,apatent502015010534.8 licensed,apatent502015010347.7licensed,and apatent102014215212.7licensed.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 8 – Angemessene Arbeitsbedingungen und wirtschaftliches Wachstum
SDG 10 – Weniger Ungleichheiten

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

2.22-17 Endokrinologie, Diabetologie, Metabolismus
2.23-08 Kognitive und systemische Humanneurowissenschaften

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10.1371/journal.pbio.3001567

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AU - Berg, Daniela

AU - Oster, Henrik

N1 - Publisher Copyright: Copyright: © 2022 Kramer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Foundations of circadian medicine

Abstract

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DFG-Fachsystematik

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