FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects

Britta K. Winkler; Hendrik Lehnert; Henrik Oster; Henriette Kirchner; Birgit Harbeck

doi:10.2217/epi-2017-0057

FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects

Britta K. Winkler, Hendrik Lehnert, Henrik Oster, Henriette Kirchner, Birgit Harbeck^*

^*Korrespondierende/r Autor/-in für diese Arbeit

10 Zitate (Scopus)

Abstract

Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects. Aim: To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short-and long-term marker for cortisol exposure in humans. Materials & methods: An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined. Results: A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses. Conclusion: Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.

Originalsprache	Englisch
Zeitschrift	Epigenomics
Jahrgang	9
Ausgabenummer	10
Seiten (von - bis)	1279-1286
Seitenumfang	8
ISSN	1750-1911
DOIs	https://doi.org/10.2217/epi-2017-0057
Publikationsstatus	Veröffentlicht - 01.10.2017

Fördermittel

H?Oster?has?a?Lichtenberg?fellowship?of?the?Volkswagen?Foundation.?H?Kirchner?is?funded?by?the?Emmy-Noether?Programm?of? the? German? Research? Foundation? (DFG).? B? Harbeck? received? a? research? grant? by? the? University? of? Luebeck.? The? authors? have? no? other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No?writing?assistance?was?utilized?in?the?production?of?this?manuscript.

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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title = "FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects",

abstract = "Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects. Aim: To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short-and long-term marker for cortisol exposure in humans. Materials \& methods: An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined. Results: A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses. Conclusion: Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.",

author = "Winkler, \{Britta K.\} and Hendrik Lehnert and Henrik Oster and Henriette Kirchner and Birgit Harbeck",

year = "2017",

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doi = "10.2217/epi-2017-0057",

language = "English",

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T1 - FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects

AU - Winkler, Britta K.

AU - Lehnert, Hendrik

AU - Oster, Henrik

AU - Kirchner, Henriette

AU - Harbeck, Birgit

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects. Aim: To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short-and long-term marker for cortisol exposure in humans. Materials & methods: An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined. Results: A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses. Conclusion: Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.

AB - Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects. Aim: To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short-and long-term marker for cortisol exposure in humans. Materials & methods: An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined. Results: A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses. Conclusion: Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.

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DO - 10.2217/epi-2017-0057

M3 - Journal articles

C2 - 28875708

AN - SCOPUS:85029928411

SN - 1750-1911

VL - 9

SP - 1279

EP - 1286

JO - Epigenomics

JF - Epigenomics

IS - 10

ER -

FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects

Abstract

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