First-Choice Antibiotics at Subinhibitory Concentrations Induce Persistence of Chlamydia pneumoniae

Jens Gieffers; Jan Rupp; Andreas Gebert; Werner Solbach; Matthias Klinger

doi:10.1128/AAC.48.4.1402-1405.2004

First-Choice Antibiotics at Subinhibitory Concentrations Induce Persistence of Chlamydia pneumoniae

Jens Gieffers^*, Jan Rupp, Andreas Gebert, Werner Solbach, Matthias Klinger

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Anatomie

47 Zitate (Scopus)

Abstract

Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.

Originalsprache	Englisch
Zeitschrift	Antimicrobial Agents and Chemotherapy
Jahrgang	48
Ausgabenummer	4
Seiten (von - bis)	1402-1405
Seitenumfang	4
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.48.4.1402-1405.2004
Publikationsstatus	Veröffentlicht - 01.04.2004

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

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10.1128/AAC.48.4.1402-1405.2004

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abstract = "Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.",

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AU - Klinger, Matthias

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AB - Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.

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U2 - 10.1128/AAC.48.4.1402-1405.2004

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First-Choice Antibiotics at Subinhibitory Concentrations Induce Persistence of Chlamydia pneumoniae

Abstract

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