Fibroblast tissue priming—not so nice to C you!

Behdad Afzali; Claudia Kemper

doi:10.1016/j.immuni.2021.04.010

Fibroblast tissue priming—not so nice to C you!

Behdad Afzali^*, Claudia Kemper

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Systemische Entzündungsforschung

National Institute of Diabetes and Digestive and Kidney Diseases

9 Zitate (Scopus)

Abstract

The molecular mechanisms explaining why relapses of inflammatory arthritis occur at previously affected sites are unknown. In this issue of Immunity, Friščić et al. propose that local fibroblasts perpetuate inflammation after priming through cell-intrinsic complement C3, which reprograms their bioenergetics and activates the inflammasome.

Originalsprache	Englisch
Zeitschrift	Immunity
Jahrgang	54
Ausgabenummer	5
Seiten (von - bis)	847-850
Seitenumfang	4
ISSN	1074-7613
DOIs	https://doi.org/10.1016/j.immuni.2021.04.010
Publikationsstatus	Veröffentlicht - 11.05.2021

Fördermittel

This work was supported in part by the Intramural Research Program of the NIH , the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (project number ZIA/DK075149 to B.A.) and the National Heart, Lung, and Blood Institute (NHLBI) (project number ZIA/Hl006223 to C.K.).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

Dokumente

10.1016/j.immuni.2021.04.010

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AB - The molecular mechanisms explaining why relapses of inflammatory arthritis occur at previously affected sites are unknown. In this issue of Immunity, Friščić et al. propose that local fibroblasts perpetuate inflammation after priming through cell-intrinsic complement C3, which reprograms their bioenergetics and activates the inflammasome.

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Fibroblast tissue priming—not so nice to C you!

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

Weitere Links

Fingerprint

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