Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression—Case Report

Jessica P.K. Doll; Jorge F. Vázquez-Castellanos; Anna Chiara Schaub; Nina Schweinfurth; Cedric Kettelhack; Else Schneider; Gulnara Yamanbaeva; Laura Mählmann; Serge Brand; Christoph Beglinger; Stefan Borgwardt; Jeroen Raes; Andreas Schmidt; Undine E. Lang

doi:10.3389/fpsyt.2022.815422

Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression—Case Report

Jessica P.K. Doll, Jorge F. Vázquez-Castellanos, Anna Chiara Schaub, Nina Schweinfurth, Cedric Kettelhack, Else Schneider, Gulnara Yamanbaeva, Laura Mählmann, Serge Brand, Christoph Beglinger, Stefan Borgwardt, Jeroen Raes, Andreas Schmidt^*, Undine E. Lang

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Psychiatrie und Psychotherapie

125 Zitate (Scopus)

Abstract

Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota and depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two patients with major depressive disorder ever treated with fecal microbiota transplantation as add-on therapy. Both improved their depressive symptoms 4 weeks after the transplantation. Effects lasted up to 8 weeks in one patient. Gastrointestinal symptoms, constipation in particular, were reflected in microbiome changes and improved in one patient. This report suggests further FMT studies in depression could be worth pursuing and adds to awareness as well as safety assurance, both crucial in determining the potential of FMT in depression treatment.

Originalsprache	Englisch
Aufsatznummer	815422
Zeitschrift	Frontiers in Psychiatry
Jahrgang	13
Seiten (von - bis)	815422
ISSN	1664-0640
DOIs	https://doi.org/10.3389/fpsyt.2022.815422
Publikationsstatus	Veröffentlicht - 17.02.2022

Fördermittel

This work was supported by the Gertrud Thalmann-Fonds (SBo, UL), Seerave Foundation (UL), Kämpf-Bötschi Stiftung (UL), and Research Fund Junior Researchers of the University of Basel (Appln 3MS1041, AS). JV-C was supported by the postdoctoral fellowships from the Research Fund–Flanders (FWO 1236321N). The Raes lab was supported by VIB, KU Leuven, and the Rega Foundation.

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SDG 3 – Gesundheit und Wohlergehen
SDG 10 – Weniger Ungleichheiten

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10.3389/fpsyt.2022.815422

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Doll, J. P. K., Vázquez-Castellanos, J. F., Schaub, A. C., Schweinfurth, N., Kettelhack, C., Schneider, E., Yamanbaeva, G., Mählmann, L., Brand, S., Beglinger, C., Borgwardt, S., Raes, J., Schmidt, A., & Lang, U. E. (2022). Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression—Case Report. Frontiers in Psychiatry, 13, 815422. Artikel 815422. https://doi.org/10.3389/fpsyt.2022.815422

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title = "Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression—Case Report",

abstract = "Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota and depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two patients with major depressive disorder ever treated with fecal microbiota transplantation as add-on therapy. Both improved their depressive symptoms 4 weeks after the transplantation. Effects lasted up to 8 weeks in one patient. Gastrointestinal symptoms, constipation in particular, were reflected in microbiome changes and improved in one patient. This report suggests further FMT studies in depression could be worth pursuing and adds to awareness as well as safety assurance, both crucial in determining the potential of FMT in depression treatment.",

author = "Doll, \{Jessica P.K.\} and V{\'a}zquez-Castellanos, \{Jorge F.\} and Schaub, \{Anna Chiara\} and Nina Schweinfurth and Cedric Kettelhack and Else Schneider and Gulnara Yamanbaeva and Laura M{\"a}hlmann and Serge Brand and Christoph Beglinger and Stefan Borgwardt and Jeroen Raes and Andreas Schmidt and Lang, \{Undine E.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Doll, V{\'a}zquez-Castellanos, Schaub, Schweinfurth, Kettelhack, Schneider, Yamanbaeva, M{\"a}hlmann, Brand, Beglinger, Borgwardt, Raes, Schmidt and Lang.",

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doi = "10.3389/fpsyt.2022.815422",

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Doll, JPK, Vázquez-Castellanos, JF, Schaub, AC, Schweinfurth, N, Kettelhack, C, Schneider, E, Yamanbaeva, G, Mählmann, L, Brand, S, Beglinger, C, Borgwardt, S, Raes, J, Schmidt, A & Lang, UE 2022, 'Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression—Case Report', Frontiers in Psychiatry, Jg. 13, 815422, S. 815422. https://doi.org/10.3389/fpsyt.2022.815422

TY - JOUR

T1 - Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression—Case Report

AU - Doll, Jessica P.K.

AU - Vázquez-Castellanos, Jorge F.

AU - Schaub, Anna Chiara

AU - Schweinfurth, Nina

AU - Kettelhack, Cedric

AU - Schneider, Else

AU - Yamanbaeva, Gulnara

AU - Mählmann, Laura

AU - Brand, Serge

AU - Beglinger, Christoph

AU - Borgwardt, Stefan

AU - Raes, Jeroen

AU - Schmidt, Andreas

AU - Lang, Undine E.

PY - 2022/2/17

Y1 - 2022/2/17

N2 - Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota and depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two patients with major depressive disorder ever treated with fecal microbiota transplantation as add-on therapy. Both improved their depressive symptoms 4 weeks after the transplantation. Effects lasted up to 8 weeks in one patient. Gastrointestinal symptoms, constipation in particular, were reflected in microbiome changes and improved in one patient. This report suggests further FMT studies in depression could be worth pursuing and adds to awareness as well as safety assurance, both crucial in determining the potential of FMT in depression treatment.

AB - Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota and depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two patients with major depressive disorder ever treated with fecal microbiota transplantation as add-on therapy. Both improved their depressive symptoms 4 weeks after the transplantation. Effects lasted up to 8 weeks in one patient. Gastrointestinal symptoms, constipation in particular, were reflected in microbiome changes and improved in one patient. This report suggests further FMT studies in depression could be worth pursuing and adds to awareness as well as safety assurance, both crucial in determining the potential of FMT in depression treatment.

UR - https://www.scopus.com/pages/publications/85125701122

U2 - 10.3389/fpsyt.2022.815422

DO - 10.3389/fpsyt.2022.815422

M3 - Journal articles

C2 - 35250668

AN - SCOPUS:85125701122

SN - 1664-0640

VL - 13

SP - 815422

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

M1 - 815422

ER -

Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression—Case Report

Abstract

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