Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma

Amir Mehdizadeh; Mohammad Hossein Somi; Masoud Darabi; Mortaza Jabbarpour-Bonyadi

doi:10.1007/s11033-016-3943-9

Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma

Amir Mehdizadeh, Mohammad Hossein Somi, Masoud Darabi, Mortaza Jabbarpour-Bonyadi^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Hämatologie und Onkologie

26 Zitate (Scopus)

Abstract

Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.

Originalsprache	Englisch
Zeitschrift	Molecular Biology Reports
Jahrgang	43
Ausgabenummer	2
Seiten (von - bis)	107-116
Seitenumfang	10
ISSN	0301-4851
DOIs	https://doi.org/10.1007/s11033-016-3943-9
Publikationsstatus	Veröffentlicht - 01.02.2016

Fördermittel

This work has been done as part of the PhD Dissertation for Amir Mehdizadeh. This study was supported by Liver and Gastrointestinal Diseases Research Center at Tabriz University of Medical Sciences (Iran; Grant number: 131/216). Authors would like to acknowledge Stem Cell Research Center at Tabriz University of Medical Sciences (Iran) for their great help.

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10.1007/s11033-016-3943-9

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abstract = "Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.",

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AU - Jabbarpour-Bonyadi, Mortaza

N1 - Funding Information: This work has been done as part of the PhD Dissertation for Amir Mehdizadeh. This study was supported by Liver and Gastrointestinal Diseases Research Center at Tabriz University of Medical Sciences (Iran; Grant number: 131/216). Authors would like to acknowledge Stem Cell Research Center at Tabriz University of Medical Sciences (Iran) for their great help. Publisher Copyright: © 2016, Springer Science+Business Media Dordrecht.

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AB - Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.

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Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma

Abstract

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