Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Wim J.E. Tissing; Melchior Lauten; Jules P.P. Meijerink; Monique L. Den Boer; Jan Willem Koper; Peter Sonneveld; Rob Pieters

Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Wim J.E. Tissing
, Melchior Lauten
, Jules P.P. Meijerink^*
, Monique L. Den Boer
, Jan Willem Koper
, Peter Sonneveld
, Rob Pieters

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Kinder- und Jugendmedizin

Erasmus Medical College

45 Zitate (Scopus)

Abstract

In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-α, GR-β and GR-P isoforms, was associated with in vitro prednisolone resistance.

Originalsprache	Englisch
Zeitschrift	Haematologica
Jahrgang	90
Ausgabenummer	9
Seiten (von - bis)	1279-1281
Seitenumfang	3
ISSN	0390-6078
Publikationsstatus	Veröffentlicht - 09.2005

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title = "Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia",

abstract = "In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-α, GR-β and GR-P isoforms, was associated with in vitro prednisolone resistance.",

author = "Tissing, \{Wim J.E.\} and Melchior Lauten and Meijerink, \{Jules P.P.\} and \{Den Boer\}, \{Monique L.\} and Koper, \{Jan Willem\} and Peter Sonneveld and Rob Pieters",

year = "2005",

month = sep,

language = "English",

volume = "90",

pages = "1279--1281",

journal = "Haematologica",

issn = "0390-6078",

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Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia. / Tissing, Wim J.E.; Lauten, Melchior; Meijerink, Jules P.P. et al.
in: Haematologica, Jahrgang 90, Nr. 9, 09.2005, S. 1279-1281.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

AU - Tissing, Wim J.E.

AU - Lauten, Melchior

AU - Meijerink, Jules P.P.

AU - Den Boer, Monique L.

AU - Koper, Jan Willem

AU - Sonneveld, Peter

AU - Pieters, Rob

PY - 2005/9

Y1 - 2005/9

N2 - In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-α, GR-β and GR-P isoforms, was associated with in vitro prednisolone resistance.

AB - In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-α, GR-β and GR-P isoforms, was associated with in vitro prednisolone resistance.

UR - https://www.scopus.com/pages/publications/25444438725

M3 - Journal articles

C2 - 16154856

AN - SCOPUS:25444438725

SN - 0390-6078

VL - 90

SP - 1279

EP - 1281

JO - Haematologica

JF - Haematologica

IS - 9

ER -

Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Abstract

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