Expression of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Acute Rejection of Human Renal Allografts

H. B. Sager*, S. Ergun, A. Hartmann, U. Hoffmann, B. K. Krämer, M. J. Mihatsch, J. Weil

*Korrespondierende/r Autor/-in für diese Arbeit
3 Zitate (Scopus)

Abstract

Background: Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed on various cell types and mediates homophilic cell adhesion. CEACAM1 plays an important role in cell morphogenesis and angiogenesis. Furthermore, CEACAM1 regulates adhesive activity of immune-competent cells, suggesting an additional role in inflammatory processes. Methods: Therefore, in the present study the expression of CEACAM1 was analysed retrospectively in renal biopsies from kidney transplant recipients (stable graft [Ctr; n = 18], acute vascular rejection [AVR; n = 14], acute tubulointerstitial rejection [AIR; n = 9], and combined vascular and interstitial rejection [AVIR; n = 7]). Expression patterns of CEACAM1 were determined using immunohistochemistry and quantitative morphometry. Results: All biopsy specimens from patients with stable grafts showed low CEACAM1 levels, suggesting a constitutive expression in renal transplants. In patients with acute rejection, CEACAM1 was markedly up-regulated. AVR revealed the highest tubular CEACAM1 levels (4.9 ± 0.5% [AVR] vs 2.2 ± 0.3% [Ctr] of tubular area; P < .05), whereas interstitial rejections showed the highest glomerular expressions (4.5 ± 0.5% [AIR] vs 0.9 ± 0.1% [Ctr] of glomerular area; P < .05). Conclusions: An up-regulated expression of CEACAM1 in tubular and/or glomerular cells is an indicator of acute inflammatory processes in biopsy specimens from patients with acute renal allograft rejections and, therefore, might be used as a new clinical marker.

OriginalspracheEnglisch
ZeitschriftTransplantation Proceedings
Jahrgang41
Ausgabenummer5
Seiten (von - bis)1536-1540
Seitenumfang5
ISSN0041-1345
DOIs
PublikationsstatusVeröffentlicht - 06.2009

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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