Exploring the hair growth-wound healing connection: Anagen phase promotes wound re-Epithelialization

David M. Ansell, Jennifer E. Kloepper, Helen A. Thomason, Ralf Paus, Matthew J. Hardman

54 Zitate (Scopus)

Abstract

When the skin is damaged, a variety of cell types must migrate, proliferate, and differentiate to reform a functional barrier to the external environment. Recent studies have shown that progenitor cells residing in hair follicles (HFs) are able to contribute to this re-epithelialization of wounds in vivo. However, the influence of the hair cycle on wound healing has not previously been addressed. Here, we have exploited spontaneous postnatal hair-cycle synchronicity in mice to systematically examine the influence of the different hair-cycle stages on murine skin wound healing. We report significant acceleration of healing during the anagen phase of HF cycling in vivo, associated with alterations in epithelial, endothelial, and inflammatory cell types. Intriguingly, gene profiling data reveal a clear correlation between the transcription of genes beneficial for wound healing and those upregulated during the anagen phase of the hair cycle in unwounded skin. These findings, which demonstrate a previously unappreciated association between HF cycling and wound healing, reveal numerous molecular correlates for further investigation.
OriginalspracheEnglisch
ZeitschriftJournal of Investigative Dermatology
Jahrgang131
Ausgabenummer2
Seiten (von - bis)518-528
Seitenumfang11
ISSN0022-202X
DOIs
PublikationsstatusVeröffentlicht - 01.02.2011

Fingerprint

Untersuchen Sie die Forschungsthemen von „Exploring the hair growth-wound healing connection: Anagen phase promotes wound re-Epithelialization“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren