Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

Xinhua Yu; Saleh M. Ibrahim

doi:10.1186/ar3490

Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

Xinhua Yu, Saleh M. Ibrahim^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Dermatologie, Allergologie und Venerologie

3 Zitate (Scopus)

Abstract

Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.

Originalsprache	Englisch
Aufsatznummer	132
Zeitschrift	Arthritis Research and Therapy
Jahrgang	13
Ausgabenummer	5
ISSN	1478-6354
DOIs	https://doi.org/10.1186/ar3490
Publikationsstatus	Veröffentlicht - 31.10.2011

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10.1186/ar3490

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Identifizierung von Anfälligkeitsgenen, die die Produktion von Autoantikörpern bei kollageninduzierter Arthritis steuern
Ibrahim, S. (Projektleiter*in (PI)) & Yu, X. (Beteiligte Person)
01.01.09 → 31.12.13
Projekt: DFG Einzelprojekte › DFG Einzelförderungen (Sachbeihilfen)

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abstract = "Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.",

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AB - Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.

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Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

Abstract

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Dokumente

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Projekte

Identifizierung von Anfälligkeitsgenen, die die Produktion von Autoantikörpern bei kollageninduzierter Arthritis steuern

Zitieren