TY - JOUR
T1 - Epigenetic regulation of cancer growth by histone demethylases
AU - Lim, Soyoung
AU - Metzger, Eric
AU - Schle, Roland
AU - Kirfel, Jutta
AU - Buettner, Reinhard
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Cancer is traditionally viewed as a primarily genetic disorder. However, it is now increasingly apparent that epigenetic abnormalities play a fundamental role in cancer development. Aberrant expression of histone-modifying enzymes has been implicated in the course of tumor initiation and progression. The discovery of a large number of histone demethylases suggests an important role for dynamic regulation of histone methylation in biological processes. The observation that overexpression, amplification or mutations of several histone demethylases have been found in many types of tumors, raise the possibility of using these enzymes as diagnostic tools as well as pave a way for the discovery of novel therapeutic targets and treatment modalities. Here, we review the current knowledge of the potential role of H3K4, H3K9 and H3K27 histone demethylases in tumorigenesis.
AB - Cancer is traditionally viewed as a primarily genetic disorder. However, it is now increasingly apparent that epigenetic abnormalities play a fundamental role in cancer development. Aberrant expression of histone-modifying enzymes has been implicated in the course of tumor initiation and progression. The discovery of a large number of histone demethylases suggests an important role for dynamic regulation of histone methylation in biological processes. The observation that overexpression, amplification or mutations of several histone demethylases have been found in many types of tumors, raise the possibility of using these enzymes as diagnostic tools as well as pave a way for the discovery of novel therapeutic targets and treatment modalities. Here, we review the current knowledge of the potential role of H3K4, H3K9 and H3K27 histone demethylases in tumorigenesis.
UR - http://www.scopus.com/inward/record.url?scp=77956636685&partnerID=8YFLogxK
U2 - 10.1002/ijc.25538
DO - 10.1002/ijc.25538
M3 - Scientific review articles
C2 - 20607829
AN - SCOPUS:77956636685
SN - 0020-7136
VL - 127
SP - 1991
EP - 1998
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 9
ER -