Endometriose - Molekularbiologische untersuchungsmethoden führen zu neuen behandlungskonzepten

Endometriosis is a common cause for infertility and chronic pain. Investigations for new therapeutic concepts are mainly aimed to achieve better life quality. New specific substances, based on molecular biological investigations, may be helpful to approach the goal of healing patients. The most common therapeutic concept is to combine operative treatment with drug therapy. The main therapeutic option today is to inhibit the estradiol biosynthesis. In addition, selective estradiol receptor modulators may inhibit the effects of estradiol. Also, selective progesterone receptor modulators are acting specifically against the proliferating potential of endometriosis. While inhibiting matrix metalloproteinases, the implantation of endometriotic tissue can be blocked. Sprouting of new vessels, which provides the potential of proliferation, could possibly be blocked by antiangiogenic substances. Using anti-inflammatory drugs, antibodies or binding proteins, the synthesis and secretion of cytokines could be inhibited.