TY - JOUR
T1 - Emerging treatments for pemphigoid diseases
AU - Ludwig, Ralf J.
AU - Kalies, Kathrin
AU - Köhl, Jörg
AU - Zillikens, Detlef
AU - Schmidt, Enno
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Incidence of bullous pemphigoid (BP), the main pemphigoid disease, has increased over the past decades. Despite growing insights into pathogenic mechanisms, treatment is still based on systemic immunosuppression. Furthermore, overall mortality is significantly increased, which can be at least partially attributed to immunosuppressive therapy. Other pemphigoid diseases are also still difficult to treat. Hence, there is a so far unmet need for novel treatment options in patients with pemphigoid disease. Based on recent advances in understanding pathogenesis, several novel potential therapeutic targets have emerged. Interestingly, for some of these targets, lead compounds have been developed. Here, we review emerging therapeutic targets for pemphigoid diseases and discuss which compounds are likely be used in the future.
AB - Incidence of bullous pemphigoid (BP), the main pemphigoid disease, has increased over the past decades. Despite growing insights into pathogenic mechanisms, treatment is still based on systemic immunosuppression. Furthermore, overall mortality is significantly increased, which can be at least partially attributed to immunosuppressive therapy. Other pemphigoid diseases are also still difficult to treat. Hence, there is a so far unmet need for novel treatment options in patients with pemphigoid disease. Based on recent advances in understanding pathogenesis, several novel potential therapeutic targets have emerged. Interestingly, for some of these targets, lead compounds have been developed. Here, we review emerging therapeutic targets for pemphigoid diseases and discuss which compounds are likely be used in the future.
UR - http://www.scopus.com/inward/record.url?scp=84881027363&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2013.06.003
DO - 10.1016/j.molmed.2013.06.003
M3 - Scientific review articles
AN - SCOPUS:84881027363
SN - 1471-4914
VL - 19
SP - 501
EP - 512
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 8
ER -