Emergence of Low-level Delamanid and Bedaquiline Resistance during Extremely Drug-resistant Tuberculosis Treatment

Silke Polsfuss; Sabine Hofmann-Thiel; Matthias Merker; David Krieger; Stefan Niemann; Holger Rüssmann; Nicolas Schönfeld; Harald Hoffmann; Katharina Kranzer

doi:10.1093/cid/ciz074

Emergence of Low-level Delamanid and Bedaquiline Resistance during Extremely Drug-resistant Tuberculosis Treatment

Silke Polsfuss^*, Sabine Hofmann-Thiel, Matthias Merker, David Krieger, Stefan Niemann, Holger Rüssmann, Nicolas Schönfeld, Harald Hoffmann, Katharina Kranzer

^*Korrespondierende/r Autor/-in für diese Arbeit

Medizinische Klinik III

14 Zitate (Scopus)

Abstract

Two new drugs, delamanid and bedaquiline, have recently been approved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis. Here, we report a case of clofazimine, bedaquiline, and low-level delamanid resistances acquired during treatment of a patient with XDR tuberculosis.

Originalsprache	Englisch
Zeitschrift	Clinical Infectious Diseases
Jahrgang	69
Ausgabenummer	7
Seiten (von - bis)	1229-1231
Seitenumfang	3
ISSN	1058-4838
DOIs	https://doi.org/10.1093/cid/ciz074
Publikationsstatus	Veröffentlicht - 13.09.2019

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

UN SDGs

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10.1093/cid/ciz074

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abstract = "Two new drugs, delamanid and bedaquiline, have recently been approved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis. Here, we report a case of clofazimine, bedaquiline, and low-level delamanid resistances acquired during treatment of a patient with XDR tuberculosis.",

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AU - Polsfuss, Silke

AU - Hofmann-Thiel, Sabine

AU - Merker, Matthias

AU - Krieger, David

AU - Niemann, Stefan

AU - Rüssmann, Holger

AU - Schönfeld, Nicolas

AU - Hoffmann, Harald

AU - Kranzer, Katharina

N1 - Publisher Copyright: © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/9/13

Y1 - 2019/9/13

N2 - Two new drugs, delamanid and bedaquiline, have recently been approved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis. Here, we report a case of clofazimine, bedaquiline, and low-level delamanid resistances acquired during treatment of a patient with XDR tuberculosis.

AB - Two new drugs, delamanid and bedaquiline, have recently been approved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis. Here, we report a case of clofazimine, bedaquiline, and low-level delamanid resistances acquired during treatment of a patient with XDR tuberculosis.

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DO - 10.1093/cid/ciz074

M3 - Journal articles

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Emergence of Low-level Delamanid and Bedaquiline Resistance during Extremely Drug-resistant Tuberculosis Treatment

Abstract

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