Electrical high frequency stimulation of the caudate nucleus induces local GABA outflow in freely moving rats

A. Hiller; S. Loeffler; C. Haupt; M. Litza; U. Hofmann; A. Moser

doi:10.1016/j.jneumeth.2006.07.023

Electrical high frequency stimulation of the caudate nucleus induces local GABA outflow in freely moving rats

A. Hiller, S. Loeffler, C. Haupt, M. Litza, U. Hofmann, A. Moser^*

^*Korrespondierende/r Autor/-in für diese Arbeit

28 Zitate (Scopus)

Abstract

Electrical high frequency stimulation of the globus pallidus internus or the subthalamic nucleus has beneficial motor effects in advanced Parkinson's disease. The mechanisms underlying these clinical results remain, however, unclear. From previous in vitro studies it is proposed that the γ-aminobutyric acid (GABA) system is involved in the effectiveness of electrical high frequency stimulation (HFS). In these experiments, we developed an in vivo model that allows for simultaneous and collocated microdialysis and HFS by electrical pulses of 124 Hz in the caudate nucleus of freely moving rats. GABA and glutamate outflow were sampled by microdialysis technique and quantified after pre-column o-phthaldialdehyde sulphite derivatization using HPLC with electrochemical detection. As the most outstanding result, we could demonstrate that high frequency stimulation significantly increased basal GABA outflow without affecting glutamate levels in freely moving rats.

Originalsprache	Englisch
Zeitschrift	Journal of Neuroscience Methods
Jahrgang	159
Ausgabenummer	2
Seiten (von - bis)	286-290
Seitenumfang	5
ISSN	0165-0270
DOIs	https://doi.org/10.1016/j.jneumeth.2006.07.023
Publikationsstatus	Veröffentlicht - 30.01.2007

Fördermittel

This study was in part supported by funds of the University of Lübeck (AH).

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10.1016/j.jneumeth.2006.07.023

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Graduiertenschule GSC 235: Informatik in Medizin und Lebenswissenschaften
Schweikard, A. (Sprecher*in), Anders, S. (Beteiligte*r Wissenschaftler*in), Barkhausen, J. (Beteiligte*r Wissenschaftler*in), Buzug, T. (Beteiligte*r Wissenschaftler*in), Erdmann, J. (Beteiligte*r Wissenschaftler*in), Fischer, B. (Beteiligte*r Wissenschaftler*in), Fischer, S. (Beteiligte*r Wissenschaftler*in), Habermann, J. K. (Beteiligte*r Wissenschaftler*in), Hartmann, E. (Beteiligte*r Wissenschaftler*in), Hilgenfeld, R. (Beteiligte*r Wissenschaftler*in), Hofmann, U. (Beteiligte*r Wissenschaftler*in), Klein, C. (Beteiligte*r Wissenschaftler*in), Kruse, C. (Beteiligte*r Wissenschaftler*in), Marshall, L. (Beteiligte*r Wissenschaftler*in), Martinetz, T. (Beteiligte*r Wissenschaftler*in), Mertins, A. (Beteiligte*r Wissenschaftler*in), Münte, T. (Beteiligte*r Wissenschaftler*in), Oltmanns, K. (Beteiligte*r Wissenschaftler*in), Schneider, S. (Beteiligte*r Wissenschaftler*in), Schunkert, H. (Beteiligte*r Wissenschaftler*in), Sczakiel, G. (Beteiligte*r Wissenschaftler*in), Tronnier, V. M. (Beteiligte*r Wissenschaftler*in), Vogel, A. (Beteiligte*r Wissenschaftler*in), Westermann, J. (Beteiligte*r Wissenschaftler*in) & Zillikens, D. (Beteiligte*r Wissenschaftler*in)
01.11.07 → 31.12.14
Projekt: DFG Verbundprojekte › DFG Graduiertenkollegs (GRK)

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title = "Electrical high frequency stimulation of the caudate nucleus induces local GABA outflow in freely moving rats",

abstract = "Electrical high frequency stimulation of the globus pallidus internus or the subthalamic nucleus has beneficial motor effects in advanced Parkinson's disease. The mechanisms underlying these clinical results remain, however, unclear. From previous in vitro studies it is proposed that the γ-aminobutyric acid (GABA) system is involved in the effectiveness of electrical high frequency stimulation (HFS). In these experiments, we developed an in vivo model that allows for simultaneous and collocated microdialysis and HFS by electrical pulses of 124 Hz in the caudate nucleus of freely moving rats. GABA and glutamate outflow were sampled by microdialysis technique and quantified after pre-column o-phthaldialdehyde sulphite derivatization using HPLC with electrochemical detection. As the most outstanding result, we could demonstrate that high frequency stimulation significantly increased basal GABA outflow without affecting glutamate levels in freely moving rats.",

author = "A. Hiller and S. Loeffler and C. Haupt and M. Litza and U. Hofmann and A. Moser",

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T1 - Electrical high frequency stimulation of the caudate nucleus induces local GABA outflow in freely moving rats

AU - Hiller, A.

AU - Loeffler, S.

AU - Haupt, C.

AU - Litza, M.

AU - Hofmann, U.

AU - Moser, A.

PY - 2007/1/30

Y1 - 2007/1/30

N2 - Electrical high frequency stimulation of the globus pallidus internus or the subthalamic nucleus has beneficial motor effects in advanced Parkinson's disease. The mechanisms underlying these clinical results remain, however, unclear. From previous in vitro studies it is proposed that the γ-aminobutyric acid (GABA) system is involved in the effectiveness of electrical high frequency stimulation (HFS). In these experiments, we developed an in vivo model that allows for simultaneous and collocated microdialysis and HFS by electrical pulses of 124 Hz in the caudate nucleus of freely moving rats. GABA and glutamate outflow were sampled by microdialysis technique and quantified after pre-column o-phthaldialdehyde sulphite derivatization using HPLC with electrochemical detection. As the most outstanding result, we could demonstrate that high frequency stimulation significantly increased basal GABA outflow without affecting glutamate levels in freely moving rats.

AB - Electrical high frequency stimulation of the globus pallidus internus or the subthalamic nucleus has beneficial motor effects in advanced Parkinson's disease. The mechanisms underlying these clinical results remain, however, unclear. From previous in vitro studies it is proposed that the γ-aminobutyric acid (GABA) system is involved in the effectiveness of electrical high frequency stimulation (HFS). In these experiments, we developed an in vivo model that allows for simultaneous and collocated microdialysis and HFS by electrical pulses of 124 Hz in the caudate nucleus of freely moving rats. GABA and glutamate outflow were sampled by microdialysis technique and quantified after pre-column o-phthaldialdehyde sulphite derivatization using HPLC with electrochemical detection. As the most outstanding result, we could demonstrate that high frequency stimulation significantly increased basal GABA outflow without affecting glutamate levels in freely moving rats.

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DO - 10.1016/j.jneumeth.2006.07.023

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Electrical high frequency stimulation of the caudate nucleus induces local GABA outflow in freely moving rats

Abstract

Fördermittel

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Graduiertenschule GSC 235: Informatik in Medizin und Lebenswissenschaften

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