Abstract
Electrical high frequency stimulation (HFS) has been used to treat various neurological and psychiatric diseases. The striatal area contributes to response learning and procedural memory. Therefore, we investigated the effect of striatal HFS application on procedural/declarative-like memory in rats. All rats were trained in a flooded Double-H maze for three days (4 trials/day) to swim to an escape platform hidden at a constant location. The starting place was the same for all trials. After each training session, HFS of the left dorsal striatum was performed over 4. h in alternating 20. min periods (during rest time, 10. a.m. to 3. p.m.). Nineteen hours after the last HFS and right after a probe trial assessing the rats' strategy (procedural vs. declarative-like memory-based choice), animals were sacrificed and the dorsal striatum was quickly removed. Neurotransmitter levels were measured by HPLC. Stimulated rats did not differ from sham-operated and control rats in acquisition performance, but exhibited altered behavior during the probe trial (procedural memory responses being less frequent than in controls). In stimulated rats, GABA levels were significantly increased in the dorsal striatum on both sides. We suggest that HFS of the dorsal striatum does not alter learning behavior in rats but influences the strategy by which the rats solve the task. Given that the HFS-induced increase of GABA levels was found 19. h after stimulation, it can be assumed that HFS has consequences lasting for several hours and which are functionally significant at a behavioral level, at least under our stimulation (frequency, timing, location, side and strength of stimulation) and testing conditions.
| Originalsprache | Englisch |
|---|---|
| Zeitschrift | Behavioural Brain Research |
| Jahrgang | 222 |
| Ausgabenummer | 2 |
| Seiten (von - bis) | 368-374 |
| Seitenumfang | 7 |
| ISSN | 0166-4328 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - 23.09.2011 |
Fördermittel
The authors would like to thank the “Deutscher Akademischer Austauschdienst” for affording this work by allocating a PhD-travel award to AS (D/09/47851), the CNRS , the University of Strasbourg and the University of Lübeck for supporting research. Furthermore, AS expresses many thanks to the members of the Laboratoire d’Imagerie et de Neurosciences Cognitives , UMR 7237, in Strasbourg for their help and support during experimentation. Our funding sources, whatever they were, had no role in study design, in the collection, analysis, and interpretation of the data, in the writing of the report, and in the decision to submit the paper for publication.
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)
UN SDGs
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