EGFR expression levels affect the mode of action of egfr-targeting monoclonal antibodies

Stefanie Derer; Stefan Lohse; Thomas Valerius

doi:10.4161/onci.24052

EGFR expression levels affect the mode of action of egfr-targeting monoclonal antibodies

Stefanie Derer, Stefan Lohse, Thomas Valerius^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Ernährungsmedizin

Christian-Albrechts Universität zu Kiel

5 Zitate (Scopus)

Abstract

Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFRspecific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant mode of action of EGFR-targeting antibodies depend on EGFR expression levels.

Originalsprache	Englisch
Aufsatznummer	e24052
Zeitschrift	OncoImmunology
Jahrgang	2
Ausgabenummer	5
ISSN	2162-4011
DOIs	https://doi.org/10.4161/onci.24052
Publikationsstatus	Veröffentlicht - 05.2013

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

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10.4161/onci.24052

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title = "EGFR expression levels affect the mode of action of egfr-targeting monoclonal antibodies",

abstract = "Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFRspecific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant mode of action of EGFR-targeting antibodies depend on EGFR expression levels.",

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AU - Derer, Stefanie

AU - Lohse, Stefan

AU - Valerius, Thomas

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N2 - Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFRspecific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant mode of action of EGFR-targeting antibodies depend on EGFR expression levels.

AB - Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFRspecific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant mode of action of EGFR-targeting antibodies depend on EGFR expression levels.

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DO - 10.4161/onci.24052

M3 - Journal articles

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VL - 2

JO - OncoImmunology

JF - OncoImmunology

IS - 5

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ER -

EGFR expression levels affect the mode of action of egfr-targeting monoclonal antibodies

Abstract

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